TARGETED CANCER THERAPY: REVIEW ARTICLE

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NOORI DALOII MOHAMMADREZA; KASHANI BAHAREH

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Journal: Tehran University Medical Journal Year:2018 | Volume:76 | Issue:4 Page(s): 231-240

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Information Journal Paper

Title

TARGETED CANCER THERAPY: REVIEW ARTICLE

Author(s)

NOORI DALOII MOHAMMADREZA | KASHANI BAHAREH | Issue Writer Certificate

Keywords

CANCERQ2

DELIVERY METHODQ1

DRUGSQ2

TARGETED THERAPYQ1

Abstract

CANCER is one of the most dangerous health problems of today modern societieswhich has an increasing rate especially in developing countries. There are manydiverse ongoing treatment attempts trying to defeat CANCER. Despite that, scientistshave been unable to find a permanent cure for this disease. In many cases althoughthere is a successful first response in patients, CANCER cells are finally able towithstand therapeutic procedures and even use chemo-resistance to take advantageof treatments to facilitate tumor growth, resulting in CANCER remission. Therefore, andmostly in recent two decades, scientists have been trying to choose their treatmentsjust as smart to be able to conquer CANCER. One of the best methods of this smartdefense is to target weak points of neoplastic cells and use them for designing DRUGS. In this case it would be most probable for CANCER cells not to have a chance to confrontand cause chemo-resistance. Total endeavors to fulfill this goal are named “ targetedCANCER therapy” . This therapeutic approach is mostly consisted of two differentprocedures: 1-designing and using specific DRUGS to target CANCER cells’ mutatedgenes; which will be defined by checking the genetic background of tumor cells foreach specific CANCER type. EGFR, RAS, VEGF and HIF-1α are among the pathwaysthat have already been used as targets. 2-The other procedure could be methods thatwould carry DRUGS directly to unhealthy cells to prevent further side effects for normalcells of patients. It would be possible by designing specific antibodies to targetantigens of neoplastic cells. Ribonucleic sequences (miRNAs and siRNAs) are alsovery promising as new DRUGS and nanoparticles have enabled us to increase drugconcentration in tumors. The ultimate goal of these new experiments is to suggestspecific DRUGS for each patient based on the nature of one's disease and geneticbackground, which will bring about "personalized medicine" era. Using valid newreferences, this review article first presents targets that are currently being used forthis TARGETED THERAPY, their logic of choice and the DRUGS that have already beenproduced for clinical trials. Smart methods of drug delivery are also presented anddiscussed afterwards.

Cites

The Effect of 8 Weeks of HICT Training on Serum Levels of BDNF and TNFα and Aerobic Power in Breast Cancer Survivors: Randomized Clinical Trial

References

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APA: Copy

NOORI DALOII, MOHAMMADREZA, & KASHANI, BAHAREH. (2018). TARGETED CANCER THERAPY: REVIEW ARTICLE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 76(4 ), 231-240. SID. https://sid.ir/paper/39619/en

Vancouver: Copy

NOORI DALOII MOHAMMADREZA, KASHANI BAHAREH. TARGETED CANCER THERAPY: REVIEW ARTICLE. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2018;76(4 ):231-240. Available from: https://sid.ir/paper/39619/en

IEEE: Copy

MOHAMMADREZA NOORI DALOII, and BAHAREH KASHANI, “TARGETED CANCER THERAPY: REVIEW ARTICLE,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 76, no. 4 , pp. 231–240, 2018, [Online]. Available: https://sid.ir/paper/39619/en

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