Differential Proteomics analysis (2D) of prostate cancer cell lines under the treatment of natural antioxidant Oleuropein

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Rakhshidan Zahra; ZAEIFIZADEH MOHAMMAD; PAHLAVAN BAHARE

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Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:41 | Issue:5 Page(s): 56-64

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Title

Differential Proteomics analysis (2D) of prostate cancer cell lines under the treatment of natural antioxidant Oleuropein

Author(s)

Rakhshidan Zahra | ZAEIFIZADEH MOHAMMAD | PAHLAVAN BAHARE | Issue Writer Certificate

Keywords

Prostate CancerQ2

OleuropeinQ1

ProteomicsQ1

Differential Protein ExpressionQ1

Abstract

Background: Prostate Cancer is the most common cancer in men. Identification of cancer nature, progress and the mechanism of its inhibition have been always scientific important issues. The aim of this study was to analyze the effect of olives Oleuropein particles on protein expression levels in Prostate Cancer cell line, LNcap. Methods: Survival test (MTT) has been applied in 8 concentrations of Oleuropein: 19, 39, 78, 156, 312, 625, 1250, and 2500 in LNcap cell line, as well differential comparative Proteomics analyses has been performed. Two dimensional electrophoresis results in relation to differential proteins have been identified by MS-MALDI-TOF-TOF approach, as their aligns have been recognized in Mascot Database. Results: Survival test demonstrates that olive Oleuropein controled LNCap cells growth and increased their roundness. LNCap cells have most been controlled in 625ppm concentration. GSTP1and DMNT1proteins have been identified as differential proteins in Oleuropein treated samples. Where comparing to controls, DMNT1 had been downregulated. On the other hand GSTP1 had been upregulated in 625 ppm Oleuropein treated samples. Conclusion: Oleuropein may be effective for inhibition of Prostate Cancer cells in LNcap cell line, by affecting protein expression, antioxidant genes expression, some transcriptional factors expression in relation with cells leading toward apoptosis direction, and metastasis activity reduction.

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APA: Copy

Rakhshidan, Zahra, ZAEIFIZADEH, MOHAMMAD, & PAHLAVAN, BAHARE. (2019). Differential Proteomics analysis (2D) of prostate cancer cell lines under the treatment of natural antioxidant Oleuropein. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 41(5 ), 56-64. SID. https://sid.ir/paper/396319/en

Vancouver: Copy

Rakhshidan Zahra, ZAEIFIZADEH MOHAMMAD, PAHLAVAN BAHARE. Differential Proteomics analysis (2D) of prostate cancer cell lines under the treatment of natural antioxidant Oleuropein. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;41(5 ):56-64. Available from: https://sid.ir/paper/396319/en

IEEE: Copy

Zahra Rakhshidan, MOHAMMAD ZAEIFIZADEH, and BAHARE PAHLAVAN, “Differential Proteomics analysis (2D) of prostate cancer cell lines under the treatment of natural antioxidant Oleuropein,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 41, no. 5 , pp. 56–64, 2019, [Online]. Available: https://sid.ir/paper/396319/en

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