THE EFFECTS OF NICOTINE INJECTION IN RAT NUCLEUS ACCUMBENS ON ANXIETY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHORBANI YEKTA BATOOL; NASEHI MOHAMMAD; KHAKPOUR SHAHRZAD; ZARRINDAST MOHAMMAD REZA; SHAFIEEKHAN YAZDAN

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ) Year:2013 | Volume:71 | Issue:2 Page(s): 71-78

Download Full-Text

Persian Verion

View:

1,402

Download:

Cites:

Information Journal Paper

Title

THE EFFECTS OF NICOTINE INJECTION IN RAT NUCLEUS ACCUMBENS ON ANXIETY

Author(s)

Keywords

ANXIETYQ3

MALE RATQ2

NICOTINEQ3

NUCLEUS ACCUMBENSQ3

Abstract

Background: Previous reports showed that NUCLEUS ACCUMBENS involved in the etiology and pathophysiology of major depression, ANXIETY and addiction. It is not clear that how these mechanisms occur in the brain. In the present study, the influence of direct NICOTINE injection in the NUCLEUS ACCUMBENS in rats’ ANXIETY-related behavior was investigated.Methods: Wistar rats were used in this study. Male Wistar rats bred in an animal house, in a temperature-controlled (22±2oC) room with a 12 hour light/darkcycle. Rats were anesthetized using intraperitoneal injection of ketamine hydrochloride and xylazine, then placed in an stereotactic instrument for microinjection cannula implantation The stainless steel guide cannula was implanted bilaterally in the right and left dorsal the NUCLEUS ACCUMBENS shell according to Paxinos and Watson atlas. After recovery, ANXIETY behavior and locomotor activity were tested. We used the elevated plus maze to test ANXIETY. This apparatus has widely been employed to test parameters of ANXIETYrelated behaviors including the open armtime percentage (%OAT), open arm entries percentage (%OAE), locomotor activity and we record effect of drugs after injection directly in the NUCLEUS ACCUMBENS on ANXIETY-related behavior.Results: Experiments showed that bilateral injections into the NUCLEUS ACCUMBENS NICOTINE, acetylcholine receptor agonist, dose 0.1 of the dose (0.05 and 0.1, 0.25, 0.5) microgram per rat caused a significant increase in the percentage of time spent in the open arms (%OAT), compared to the control group. We did not record any significant change locomotor activity and open arm entries percentage (%OAE) in rats.Conclusion: Nicotinic receptors in the NUCLEUS ACCUMBENS shell involved to ANXIETYlike behavior in MALE RATs.

Cites

No record.

References

No record.

Cite

APA: Copy

GHORBANI YEKTA, BATOOL, NASEHI, MOHAMMAD, KHAKPOUR, SHAHRZAD, ZARRINDAST, MOHAMMAD REZA, & SHAFIEEKHAN, YAZDAN. (2013). THE EFFECTS OF NICOTINE INJECTION IN RAT NUCLEUS ACCUMBENS ON ANXIETY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 71(2), 71-78. SID. https://sid.ir/paper/39639/en

Vancouver: Copy

GHORBANI YEKTA BATOOL, NASEHI MOHAMMAD, KHAKPOUR SHAHRZAD, ZARRINDAST MOHAMMAD REZA, SHAFIEEKHAN YAZDAN. THE EFFECTS OF NICOTINE INJECTION IN RAT NUCLEUS ACCUMBENS ON ANXIETY. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2013;71(2):71-78. Available from: https://sid.ir/paper/39639/en

IEEE: Copy

BATOOL GHORBANI YEKTA, MOHAMMAD NASEHI, SHAHRZAD KHAKPOUR, MOHAMMAD REZA ZARRINDAST, and YAZDAN SHAFIEEKHAN, “THE EFFECTS OF NICOTINE INJECTION IN RAT NUCLEUS ACCUMBENS ON ANXIETY,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 71, no. 2, pp. 71–78, 2013, [Online]. Available: https://sid.ir/paper/39639/en

Related Journal Papers