TREATMENT OF LABIAL ADHESION WITH TOPICAL ESTROGEN AND CORRELATION WITH SERUM ESTRADIOL LEVEL

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SAFAIAN BARANAK; SHOKRI SIMA; KESHAVARS MOHAMADIAN SAKINEH; CHERAGHALI FATEMEH; JOIBAR LEILA; ARYAN NEJAD SAFA; RAMIM TAYEB

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Journal: Tehran University Medical Journal Year:2013 | Volume:71 | Issue:2 Page(s): 96-101

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Title

TREATMENT OF LABIAL ADHESION WITH TOPICAL ESTROGEN AND CORRELATION WITH SERUM ESTRADIOL LEVEL

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Keywords

ESTROGEN CREAMQ2

LABIA ADHESIONQ2

SERUM ESTRADIOLQ2

Abstract

Background: SERUM ESTRADIOL level is a controversial prognostic factor in the outcome of labial adhesion. The aim of this study was to evaluate SERUM ESTRADIOL levels and topical estrogen response in patients with labial adhesion.Methods: A prospective interventional study was conducted among girls with labial adhesion that referred to Pediatrics clinic in Taleghani University Hospital, Gorgan city, Iran in 2011. One hundred patients entered the study. The diagnosis was conducted by clinical examination of vestibule area. Inclusion criteria were, three months to eight years old prepuberty girls, no ambiguous genitalia, lack of vulvovaginitis symptoms, labial adhesion more than twenty five percent, no history of previous topical estrogen treatment since two weeks ago and previous incomplete treatment. The patients who did not use proper amount and duration of drug and also with adverse drug reactions during treatment period were excluded from the study.Results: The maximum frequency of labial adhesion was in the group of less than one year old. The minimum frequency of labial adhesion was in the 7-8 years old group.Eighty six patients had complete or partial remission. No evidence of an improvement was observed in fourteen children. Severity of adhesions did not worsen in our patients.Serum estradiol levels were lower in patients who had a positive response to treatment.There were significant differences in SERUM ESTRADIOL levels between full or relative improvement with no improvement groups (P=0.044).Conclusion: Findings of this study showed that the labial adhesion patients with low SERUM ESTRADIOL level had better treatment response after using topical estrogen.

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APA: Copy

SAFAIAN, BARANAK, SHOKRI, SIMA, KESHAVARS MOHAMADIAN, SAKINEH, CHERAGHALI, FATEMEH, JOIBAR, LEILA, ARYAN NEJAD, SAFA, & RAMIM, TAYEB. (2013). TREATMENT OF LABIAL ADHESION WITH TOPICAL ESTROGEN AND CORRELATION WITH SERUM ESTRADIOL LEVEL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 71(2), 96-101. SID. https://sid.ir/paper/39642/en

Vancouver: Copy

SAFAIAN BARANAK, SHOKRI SIMA, KESHAVARS MOHAMADIAN SAKINEH, CHERAGHALI FATEMEH, JOIBAR LEILA, ARYAN NEJAD SAFA, RAMIM TAYEB. TREATMENT OF LABIAL ADHESION WITH TOPICAL ESTROGEN AND CORRELATION WITH SERUM ESTRADIOL LEVEL. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2013;71(2):96-101. Available from: https://sid.ir/paper/39642/en

IEEE: Copy

BARANAK SAFAIAN, SIMA SHOKRI, SAKINEH KESHAVARS MOHAMADIAN, FATEMEH CHERAGHALI, LEILA JOIBAR, SAFA ARYAN NEJAD, and TAYEB RAMIM, “TREATMENT OF LABIAL ADHESION WITH TOPICAL ESTROGEN AND CORRELATION WITH SERUM ESTRADIOL LEVEL,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 71, no. 2, pp. 96–101, 2013, [Online]. Available: https://sid.ir/paper/39642/en

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