Therapeutic potential of cell therapy in the repair of hair cells and spiral ganglion neurons: review article

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NIKNAZAR SOMAYEH; Simani Leila; PEYVANDI HASSAN; PEYVANDI ALI ASGHAR

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Journal: Tehran University Medical Journal Year:2019 | Volume:77 | Issue:8 Page(s): 469-475

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Title

Therapeutic potential of cell therapy in the repair of hair cells and spiral ganglion neurons: review article

Author(s)

NIKNAZAR SOMAYEH | Simani Leila | PEYVANDI HASSAN | PEYVANDI ALI ASGHAR | Issue Writer Certificate

Keywords

auditory hair cellsQ1

spiral ganglion neuronsQ1

stem cellsQ2

Abstract

The mammalian cochlea is a highly complex structure which contains several cells, including sensory receptor or hair cells. The main function of the cochlear hair cells is to convert the mechanical vibrations of the sound into electrical signals, then these signals travel to the brain along the auditory nerve. auditory hair cells in some amphibians, reptiles, fish, and birds can regenerate or replace by new cells, but irreversible damage to the mammalian hair cells are not being replaced through differentiation of the internal epithelial cells in the inner ear. Indeed, mammalian auditory hair cells do not spontaneously repair or regenerate after development. Sometimes, functions of damaged hair cells may be restored, but in most cases, there is no such possibility and permanent hearing loss occurs. Several factors such as chronic ear infections, genetic disorders, drug abuse, acoustic trauma and aging can damage the cochlea, resulting in permanent hearing loss. More than 250 million people in the world have disabling hearing impairment...

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APA: Copy

NIKNAZAR, SOMAYEH, Simani, Leila, PEYVANDI, HASSAN, & PEYVANDI, ALI ASGHAR. (2019). Therapeutic potential of cell therapy in the repair of hair cells and spiral ganglion neurons: review article. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 77(8 ), 469-475. SID. https://sid.ir/paper/396481/en

Vancouver: Copy

NIKNAZAR SOMAYEH, Simani Leila, PEYVANDI HASSAN, PEYVANDI ALI ASGHAR. Therapeutic potential of cell therapy in the repair of hair cells and spiral ganglion neurons: review article. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2019;77(8 ):469-475. Available from: https://sid.ir/paper/396481/en

IEEE: Copy

SOMAYEH NIKNAZAR, Leila Simani, HASSAN PEYVANDI, and ALI ASGHAR PEYVANDI, “Therapeutic potential of cell therapy in the repair of hair cells and spiral ganglion neurons: review article,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 77, no. 8 , pp. 469–475, 2019, [Online]. Available: https://sid.ir/paper/396481/en

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