CLINICAL COURSE OF MYELODYSPLASTIC SYNDROME

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SEDIGHI S.; MONADIZADEH D.

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Paper Information

Journal: MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY Year:2005 | Volume:14 | Issue:2 Page(s): 93-98

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Information Journal Paper

Title

CLINICAL COURSE OF MYELODYSPLASTIC SYNDROME

Author(s)

SEDIGHI S. | MONADIZADEH D. | Issue Writer Certificate

Keywords

MYELODYSPLASTIC SYNDROMEQ4

PROGNOSISQ3

Abstract

Background: MYELODYSPLASTIC SYNDROME (MDS) is a group of neoplastic disorder of hematopoietic stem cells characterized by ineffective hematopoiesis. This study was performed to evaluate the clinical course of MDS and determine factors influencing survival in agroup of Iranian patients.Material and methods: During this descriptive-analytical study, clinical manifestations, pathologic and cytogenetic findings of 80 patients with MDS referring during a 16-year period to Modarres and Mehrdad hospitals in Tehran were reviewed.Results: The mean age (± standard deviation) was 57.6±17.6 years (13-85 years). The M/F ratio was 1.6/1. The frequency of the FAB subtypes were: refractory anemia (RA) and refractory anemia with ringed sideroblasts (RARS) 54%, refractory anemia with excess blasts (RAEB) 19%, chronic myelomonocytic leukemia (CMML) 15/5%, refractory anemia with excess blasts in transformation (RAEBT) 11/5%. Anemia was by far the most common symptom (78%). Kaplan-Meier analysis revealed a median survival of 14.6 months and a mean of 21 months. Leukemia occurred in 64% of females and 35.8% of males. The major variables predictive of survival were age, sex, WBC count, LDH, subtype, and the percentage of blasts in peripheral blood smear and bone marrow, however, COX regression revealed the percentage of blasts in the bone marrow as the only independent variable for determining survival (P=0.002).Conclusion: Comparing our data with several other studies one could note that the age of our patients with MDS is lower than western population. Leukemia is more frequent among females and the major prognostic features lie in the percentage of blasts in the bone marrow.

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APA: Copy

SEDIGHI, S., & MONADIZADEH, D.. (2005). CLINICAL COURSE OF MYELODYSPLASTIC SYNDROME. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 14(2), 93-98. SID. https://sid.ir/paper/397965/en

Vancouver: Copy

SEDIGHI S., MONADIZADEH D.. CLINICAL COURSE OF MYELODYSPLASTIC SYNDROME. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2005;14(2):93-98. Available from: https://sid.ir/paper/397965/en

IEEE: Copy

S. SEDIGHI, and D. MONADIZADEH, “CLINICAL COURSE OF MYELODYSPLASTIC SYNDROME,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 14, no. 2, pp. 93–98, 2005, [Online]. Available: https://sid.ir/paper/397965/en

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