THE STUDY OF MEAN CHANGES IN FASTING GLUCOSE LEVEL AND BMI IN PSYCHOTIC PATIENTS TREATED WITH OLANZAPINE IN SHAFA HOSPITAL AND PRIVATE CLINICS OF RASHT IN 2005-2006

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MODABERNIA M.J.; SHOJAIE TEHRANI H.; DJALALY H.

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Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2006 | Volume:15 | Issue:60 Page(s): 17-25

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Title

THE STUDY OF MEAN CHANGES IN FASTING GLUCOSE LEVEL AND BMI IN PSYCHOTIC PATIENTS TREATED WITH OLANZAPINE IN SHAFA HOSPITAL AND PRIVATE CLINICS OF RASHT IN 2005-2006

Author(s)

MODABERNIA M.J. | SHOJAIE TEHRANI H. | DJALALY H. | Issue Writer Certificate

Keywords

ANTI PSYCHOTICQ2

BLOOD GLUCOSEQ3

BODY MASSS INDEXQ3

OLANZAPINEQ3

PSYCHOTIC DISORDERSQ3

Abstract

Introduction: New ANTI PSYCHOTIC drugs (atypical) have fewer extra pyramidal adverse effects and more therapeutic effects in comparison with the old ones. There is no agreement on the effects of new antipsychotics on the BMI and rising BLOOD GLUCOSE.Objective: This study was done to investigate above adverse effects (raising BLOOD GLUCOSE and BMI) in the psychotic patients who were treated with OLANZAPINE in Shafa hospital and private clinic during 2005-2006.Materials and Methods: In this descriptive- analytic (study a population in two periods of time) 150 individuals who referred to previous mentioned centers were chosen. Inclusion Criteria were: diagnosis of psychosis according to DSMIV, using OLANZAPINE as treatment and having FBS less than 110 mg/lit. Exclusion criteria included: those who had inadequate response or had no tolerance to OLANZAPINE, users of other psychothropic and substance and those who had received long term Antipsychotics during the last month.Their BMI and fasting BLOOD GLUCOSE were measured before and after the study. More over, some variables such as the history of Diabetes Mellitus in the family, type of psychosis, gender and age were asked through an specific questionnaire which had been designed for this purpose. Then we collected the data in two periods. These data were analyzed through SPSS 11/5 while using the appropriate statistical tool and α=0.05 was accepted.Results : From total 150 individuals 79(52/7%) were female and 71(47/3%) were male. 16 of them had a FBS more than 110 mg/d lit. 11(7/33%) individuals showed Diabetes and 5(3/33%) individuals showed some disturbance in FBS. There were significant difference between the mean changes of BLOOD GLUCOSE (paired t p<0.0001) and also average body mass index changes (paired t p<0/0001) before and after treatment was statistically significant. There were no significant correlation between changes of body mass index and fasting BLOOD GLUCOSE in base and end point (p=0/218,0/249). Among studied variables, the most significant relationship statistically was with changes of FBS and OLANZAPINE 10 mg a day (p<0.006) and ages over 45 p<0.006.Changes of fasting BLOOD GLUCOSE had a marginal relationship with schizophrenia (p=0.55), and the other variables (such as gender, family history of Diabetes) had no statistically significant relationship with the changes of glucose level. There was also no relationship between the gender and the incidence of diabetes (p=0.68).There are significant difference between changes of FBS and using more than 10 mg daily OLANZAPINE(p<0/006) and also between changes of FBS and ages over 45(p<0.006) and schizophrenic patients p=0.055.Conclusion: This study demonstrated that mean changes of fasting BLOOD GLUCOSE and BMI after using OLANZAPINE in psychotic patients is statistically significant.Prescription of OLANZAPINE in schizophrenic patients who are over 45 and those who use more than 10mg a day of OLANZAPINE should be done more cautiously. Additional investigation by using clinical trial would offer more precise results.

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APA: Copy

MODABERNIA, M.J., SHOJAIE TEHRANI, H., & DJALALY, H.. (2006). THE STUDY OF MEAN CHANGES IN FASTING GLUCOSE LEVEL AND BMI IN PSYCHOTIC PATIENTS TREATED WITH OLANZAPINE IN SHAFA HOSPITAL AND PRIVATE CLINICS OF RASHT IN 2005-2006. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 15(60), 17-25. SID. https://sid.ir/paper/39801/en

Vancouver: Copy

MODABERNIA M.J., SHOJAIE TEHRANI H., DJALALY H.. THE STUDY OF MEAN CHANGES IN FASTING GLUCOSE LEVEL AND BMI IN PSYCHOTIC PATIENTS TREATED WITH OLANZAPINE IN SHAFA HOSPITAL AND PRIVATE CLINICS OF RASHT IN 2005-2006. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;15(60):17-25. Available from: https://sid.ir/paper/39801/en

IEEE: Copy

M.J. MODABERNIA, H. SHOJAIE TEHRANI, and H. DJALALY, “THE STUDY OF MEAN CHANGES IN FASTING GLUCOSE LEVEL AND BMI IN PSYCHOTIC PATIENTS TREATED WITH OLANZAPINE IN SHAFA HOSPITAL AND PRIVATE CLINICS OF RASHT IN 2005-2006,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 60, pp. 17–25, 2006, [Online]. Available: https://sid.ir/paper/39801/en

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