THE COMPARISON OF DIFFERENT PROPOFOL DOSE FOR ANESTHESIA INDUCTION BASED ON BIS (BISPECTRAL INDEX) MONITORING

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NADERI B.; HAGHIGHI MOHAMMAD; SEDIGHINEZHAD ABAS; MOHAMMADZADEH ALI; MIRZA ZADEH B.

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Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:17 | Issue:65 Page(s): 88-93

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Title

THE COMPARISON OF DIFFERENT PROPOFOL DOSE FOR ANESTHESIA INDUCTION BASED ON BIS (BISPECTRAL INDEX) MONITORING

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Keywords

BISQ3

PROPOFOLQ3

TIVAQ3

Abstract

Introduction: PROPOFOL is a new intravenous hypnotic drug that in combine with a short acting opioid have been used in total intravenous anesthesia (TIVA). The BIS provides additional information for standard monitoring techniques to recognize depth of sleep and achieve the appropriate dose of drug.Objective: Comparison of different PROPOFOL dose for anesthesia induction based on BIS (BISpectral index) monitoring.Materials and Methods: forty five patients with ASA class I, II who underwent surgical operation on leg fracture were randomly assigned to 3 groups. Group A with a PROPOFOL dose of 1 mg/kg, Group B at a dose of 1.5 mg/kg and Group C at a dose of 2 mg/kg were studied .Remifentanyl (0.5 mcg/kg) was added to PROPOFOL as opioid drug. The method of BIS index (50-60) has been used for determination of consciousness level and the depth of sleep and for achieving the appropriate dose of PROPOFOL. The patients were evaluated to determine occurrence of hypotension, bradycardia, the presence of intubation movement and the autonomic signs.Results: The mean levels of BIS was 58.8±9.85 in the Group A, 50.2±6.55 in Group B, and 44±5.65 in Group C. Comparison between the mean levels of BIS revealed that the Group A was significantly different with the other two groups (p=0.009). Optimum level of BIS was significantly different in 3 groups. group B (%66.7), group A (%40), group C (%20), less than of all groups (P=0.034). Hypertension incidence following intubation in group A was 33.3% and Group B was (%6.7) and in group C wasn’t any hypertension which detected a significantly different between three groups (P=0.018). Regarding to need further PROPOFOL dose, there was a significant difference (P<0.001). In group A, it was in %40 of cases, and in groups B and C it was not observed.Regarding to tachycardia, bradycardia, hypotension, movement and autonomic signs, there was no significantly different between 3 groups.Conclusion: It was appeared that group A is not appropriate due to incompatible with BIS, need Further PROPOFOL dose and hypertension. Considering the best BIS level in group B and lack of any benefit in group C for further PROPOFOL in achieving the optimum level of BIS (50-60), can be concluded that group B with PROPOFOL (1.5 mg/kg) is the best dose for achieving the desired level of BIS with remifentanil at the mentioned dose.

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APA: Copy

NADERI, B., HAGHIGHI, MOHAMMAD, SEDIGHINEZHAD, ABAS, MOHAMMADZADEH, ALI, & MIRZA ZADEH, B.. (2008). THE COMPARISON OF DIFFERENT PROPOFOL DOSE FOR ANESTHESIA INDUCTION BASED ON BIS (BISPECTRAL INDEX) MONITORING. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 17(65), 88-93. SID. https://sid.ir/paper/39859/en

Vancouver: Copy

NADERI B., HAGHIGHI MOHAMMAD, SEDIGHINEZHAD ABAS, MOHAMMADZADEH ALI, MIRZA ZADEH B.. THE COMPARISON OF DIFFERENT PROPOFOL DOSE FOR ANESTHESIA INDUCTION BASED ON BIS (BISPECTRAL INDEX) MONITORING. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;17(65):88-93. Available from: https://sid.ir/paper/39859/en

IEEE: Copy

B. NADERI, MOHAMMAD HAGHIGHI, ABAS SEDIGHINEZHAD, ALI MOHAMMADZADEH, and B. MIRZA ZADEH, “THE COMPARISON OF DIFFERENT PROPOFOL DOSE FOR ANESTHESIA INDUCTION BASED ON BIS (BISPECTRAL INDEX) MONITORING,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 65, pp. 88–93, 2008, [Online]. Available: https://sid.ir/paper/39859/en

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