EFFECTS OF HARMANE, NORHARMANE AND HARMINE ON WRITHING BEHAVIOR INDUCED BY ACETIC ACID IN MICE

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FARZIN D.; MOUSAVI E.

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Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2011 | Volume:19 | Issue:76 Page(s): 29-37

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Information Journal Paper

Title

EFFECTS OF HARMANE, NORHARMANE AND HARMINE ON WRITHING BEHAVIOR INDUCED BY ACETIC ACID IN MICE

Author(s)

FARZIN D. | MOUSAVI E. | Issue Writer Certificate

Keywords

PAINQ2

CARBOLINSQ3

HARMINEQ2

MOUSEQ3

Abstract

Introduction: The b-carbolines harmane, HARMINE and norharmane are the members of Harmala,s alkaloids group (Peganum harmala, Zygophillaceae). The b-carboline alkaloids adjoined to benzodiazepine site of the g-aminobutyric acid type A (GABAA). These alkaloids also inhibited cyclooxygenase and lipoxygenase activities. These findings showed that the b-carbolines should be able to reduce writhing nociceptio induced by acetic acid- in mice. Objective: To assess the effects of acute treatment with harmane, norharmane and HARMINE on the writhing induced by acetic acid in mice.Materials and Methods: The experiments were carried out on male BALB/C mice (20-25g). Intraperitoneal (I.p) injection of acetic acid (0.6%) was performed in order to cause writhing behavior. This behavior was recorded by direct observation for a 30-minutes period. Decrease of writhing count is indicative of an anti-nociception. In order to avoid the possibility of a physicochemical interaction between them, Drugs were administered on opposite sides of peritoned.Results: Intraperitoneal (I.p) injection of Harmane (5-20mg/kg) on 6-9 mice, norharmane (5-15mg/kg) on 8-9 mice and HARMINE (10-15mg/kg) on 8-9 mice in per group decreased the writhing behavior significantly (P<0.0001, P<0.0003 and P<0.0016, respectively). The inhibitory effects of the mentioned drugs were antagonized by flumazenil (2 mg/kg).Conclusion: Effects of harmane, norharmane and HARMINE on writhing response may be mediated through an inverse agonistic mechanism located in the benzodiazepine receptors.

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APA: Copy

FARZIN, D., & MOUSAVI, E.. (2011). EFFECTS OF HARMANE, NORHARMANE AND HARMINE ON WRITHING BEHAVIOR INDUCED BY ACETIC ACID IN MICE. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 19(76), 29-37. SID. https://sid.ir/paper/39935/en

Vancouver: Copy

FARZIN D., MOUSAVI E.. EFFECTS OF HARMANE, NORHARMANE AND HARMINE ON WRITHING BEHAVIOR INDUCED BY ACETIC ACID IN MICE. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;19(76):29-37. Available from: https://sid.ir/paper/39935/en

IEEE: Copy

D. FARZIN, and E. MOUSAVI, “EFFECTS OF HARMANE, NORHARMANE AND HARMINE ON WRITHING BEHAVIOR INDUCED BY ACETIC ACID IN MICE,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 76, pp. 29–37, 2011, [Online]. Available: https://sid.ir/paper/39935/en

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