THE ASSOCIATION OF VITAMIN D RECEPTOR GENE BSMI POLYMORPHISM WITH MULTIPLE SCLEROSIS IN IRANIAN PATIENTS

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NIKSERESHT A.R.; DADKHAH BATOUL; KAMALI SARVESTANI E.

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Journal: Journal of Kerman University of Medical Sciences Year:2009 | Volume:16 | Issue:2 Page(s): 116-123

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Title

THE ASSOCIATION OF VITAMIN D RECEPTOR GENE BSMI POLYMORPHISM WITH MULTIPLE SCLEROSIS IN IRANIAN PATIENTS

Author(s)

NIKSERESHT A.R. | DADKHAH BATOUL | KAMALI SARVESTANI E. | Issue Writer Certificate

Keywords

MULTIPLE SCLEROSISQ2

VITAMIN DQ2

POLYMORPHISMQ2

IRANQ2

Abstract

Background & Aims: 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3), the biologically active form of VITAMIN D, exerts an immunosuppressive effect through binding to its specific nuclear receptor. The present case-control study was done to examine the possible association of BsmI POLYMORPHISM in VITAMIN D receptor gene (VDR gene) with severity of MULTIPLE SCLEROSIS (MS). Methods: 267 IRANian patients with MS and 292 ethnically and sex matched controls were included in this study. BsmI POLYMORPHISM in VDR gene was assessed by PCR-RFLP method. Results: No differences in the allelic distribution were observed in the patients as compared to the controls. Also no difference in genotype distribution of VDR-BsmI POLYMORPHISM was observed between patients and controls (p=0.43). Conclusion: Considering the significance of VITAMIN D3 as an immune system regulator and its inhibitory effects on MS, investigation on other VDR gene POLYMORPHISMs is recommended.

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APA: Copy

NIKSERESHT, A.R., DADKHAH, BATOUL, & KAMALI SARVESTANI, E.. (2009). THE ASSOCIATION OF VITAMIN D RECEPTOR GENE BSMI POLYMORPHISM WITH MULTIPLE SCLEROSIS IN IRANIAN PATIENTS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 16(2), 116-123. SID. https://sid.ir/paper/4/en

Vancouver: Copy

NIKSERESHT A.R., DADKHAH BATOUL, KAMALI SARVESTANI E.. THE ASSOCIATION OF VITAMIN D RECEPTOR GENE BSMI POLYMORPHISM WITH MULTIPLE SCLEROSIS IN IRANIAN PATIENTS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;16(2):116-123. Available from: https://sid.ir/paper/4/en

IEEE: Copy

A.R. NIKSERESHT, BATOUL DADKHAH, and E. KAMALI SARVESTANI, “THE ASSOCIATION OF VITAMIN D RECEPTOR GENE BSMI POLYMORPHISM WITH MULTIPLE SCLEROSIS IN IRANIAN PATIENTS,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 2, pp. 116–123, 2009, [Online]. Available: https://sid.ir/paper/4/en

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