Iranian Turkmen blood donors determining the HPA-1 gene frequency in 1397

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Nozari mirarkolaei M.; ZADSAR M.; SAMIEE SH.; SHAIEGAN M.

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Journal Paper

Paper Information

Journal: The Scientific Journal of Iranian Blood Transfusion Year:2020 | Volume:17 | Issue:1 Page(s): 12-19

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Title

Iranian Turkmen blood donors determining the HPA-1 gene frequency in 1397

Author(s)

Nozari mirarkolaei M. | ZADSAR M. | SAMIEE SH. | SHAIEGAN M. | Issue Writer Certificate

Keywords

Blood DonorsQ2

GenotypeQ2

IranQ3

Abstract

Background and Objectives: Human platelet antigens (HPAs) are polymorphic structures located on the membrane of platelets (PLTs). These antigens have important role in clinical situations like refractoriness to platelet transfusion which is the most important cause of transfusion related mortality and morbidity in patients by recurrent platelet transfusion. Alloimmunization against the human platelet antigen 1 (HPA-1) is assumed as the major cause of platelet refractoriness in white population. Due to the variation of platelet antigens frequencies among ethnic groups; in this study, we investigated the frequency of HPA-1 alleles on Turkmen Blood Donors. Materials and Methods: In this descriptive study, 80 non-relatives of Turkmen donors were randomly sampled from Aq Qala blood center during the year 2018. Results: The mean age of the subjects was 38. 2 ± 7. 7 years (range: 18-59 years) and all were male. Molecular genotyping of HPA-1 in this study revealed that HPA-1a allele was detected in 96% donors and the HPA-1a/1b heterozygote was found in 4% of individuals. No one was HPA-1bb homozygous (frequency 0%). Conclusions: It was declared that 96% of Turkmen Blood Donors have shown HPA-1a similar to the frequency which was previously detected in Iranian Blood Donors and HPA-1b/b homozygous was not found in all donors. So it could be concluded that HPA-1a alloimmunization may not be involved in platelet refractoriness in Turkmen ethnicity.

Cites

Platelet antigens and antibodies in multitransfused patients

References

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APA: Copy

Nozari mirarkolaei, M., ZADSAR, M., SAMIEE, SH., & SHAIEGAN, M.. (2020). Iranian Turkmen blood donors determining the HPA-1 gene frequency in 1397. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), 17(1 ), 12-19. SID. https://sid.ir/paper/400030/en

Vancouver: Copy

Nozari mirarkolaei M., ZADSAR M., SAMIEE SH., SHAIEGAN M.. Iranian Turkmen blood donors determining the HPA-1 gene frequency in 1397. THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON)[Internet]. 2020;17(1 ):12-19. Available from: https://sid.ir/paper/400030/en

IEEE: Copy

M. Nozari mirarkolaei, M. ZADSAR, SH. SAMIEE, and M. SHAIEGAN, “Iranian Turkmen blood donors determining the HPA-1 gene frequency in 1397,” THE SCIENTIFIC JOURNAL OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (KHOON), vol. 17, no. 1 , pp. 12–19, 2020, [Online]. Available: https://sid.ir/paper/400030/en

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