ASSESSMENT OF RELATIONSHIP BETWEEN CENTRAL NERVOUS SYSTEM BLEEDING IN FACTOR XIII DEFICIENCY AND THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR POLYMORPHISM

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NADERI M.; DORGALALEH A.; ALIZADEH SH.; KAZEMI A.; DARGAHI H.; TABIBIAN SH.; YOUNESI M.R.; KASHANI KHATIB Z.

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Title

ASSESSMENT OF RELATIONSHIP BETWEEN CENTRAL NERVOUS SYSTEM BLEEDING IN FACTOR XIII DEFICIENCY AND THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR POLYMORPHISM

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Keywords

FACTOR XIII DEFICIENCYQ2

INTRACRANIAL HEMORRHAGEQ2

THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITORQ2

Abstract

Background: Central nervous system bleeding is a common but life threatening complication in patients with FACTOR XIII DEFICIENCY. The aim of this study was to assess the relationship between central nervous system bleeding with a common polymorphism of THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR (TAFI).Material and Methods: This case control study was performed on 34 patients with FACTOR XIII DEFICIENCY and history of CNS bleeding and 36 patients with FACTOR XIII DEFICIENCY without CNS bleeding as control group. Initially all patients were molecularly analyzed for FACTOR XIII DEFICIENCY, then both groups were assessed for TAFI Thr325Ile polymorphism. Finally obtained data was analyzed by independent t-test.Results: Molecular analysis of TAFI Thr325Ile polymorphism revealed that 89% of patients with CNS bleeding had this mutation and 67% of patients were homozygote. There is a significant relationship between Thr325Ile polymorphism in homozygote manner with incidence of CNS bleeding in factor XIII deficient (OR 18.9, 95% CI 3.8 to 95.1).Conclusion: It seems that Thr325Ile polymorphism is an important prognostic factor of CNS bleeding in patients with FACTOR XIII DEFICIENCY and increases the risk of CNS bleeding by 20 fold.

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APA: Copy

NADERI, M., DORGALALEH, A., ALIZADEH, SH., KAZEMI, A., DARGAHI, H., TABIBIAN, SH., YOUNESI, M.R., & KASHANI KHATIB, Z.. (2013). ASSESSMENT OF RELATIONSHIP BETWEEN CENTRAL NERVOUS SYSTEM BLEEDING IN FACTOR XIII DEFICIENCY AND THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR POLYMORPHISM. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 16(7 (76)), 84-90. SID. https://sid.ir/paper/400929/en

Vancouver: Copy

NADERI M., DORGALALEH A., ALIZADEH SH., KAZEMI A., DARGAHI H., TABIBIAN SH., YOUNESI M.R., KASHANI KHATIB Z.. ASSESSMENT OF RELATIONSHIP BETWEEN CENTRAL NERVOUS SYSTEM BLEEDING IN FACTOR XIII DEFICIENCY AND THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR POLYMORPHISM. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2013;16(7 (76)):84-90. Available from: https://sid.ir/paper/400929/en

IEEE: Copy

M. NADERI, A. DORGALALEH, SH. ALIZADEH, A. KAZEMI, H. DARGAHI, SH. TABIBIAN, M.R. YOUNESI, and Z. KASHANI KHATIB, “ASSESSMENT OF RELATIONSHIP BETWEEN CENTRAL NERVOUS SYSTEM BLEEDING IN FACTOR XIII DEFICIENCY AND THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR POLYMORPHISM,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 16, no. 7 (76), pp. 84–90, 2013, [Online]. Available: https://sid.ir/paper/400929/en

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