Relationship between serum levels of oxidants, antioxidants, inflammatory factor and nitric oxide in diabetic and non-smoker coronary artery disease patients

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KHAKI KHATIBI FATEMEH

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Paper Information

Journal: MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:42 | Issue:2 Page(s): 152-159

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Title

Relationship between serum levels of oxidants, antioxidants, inflammatory factor and nitric oxide in diabetic and non-smoker coronary artery disease patients

Author(s)

KHAKI KHATIBI FATEMEH | Issue Writer Certificate

Keywords

Total AntioxidantQ1

MDAQ1

Inflammatory factorQ1

Nitric oxideQ2

Coronary Artery DiseaseQ2

Non-SmokerQ1

Abstract

Background: Coronary Artery Disease (CAD) is caused by atherosclerosis. Studies have shown that many factors are closely linked to the development and progression of CAD, which include lipid peroxidation, inflammation, lack of relaxant factors and antioxidants. The aim of this study was to evaluate the above-mentioned risk factors in diabetic and Non-Smoker Coronary Artery Disease patients, by measuring these parameters, patients with atherosclerosis can be diagnosed and treated in people. Methods: In this study, 50 patients with CAD and 50 normal patients with matched age and sex and without CAD as a control were studied. Lipid Profile level were measured by standard methods. The activity of the SOD, GPX, and TAC enzymes in the samples was evaluated using a RandomX kit. Hs-CRP levels were determined by Immunoturbidometric method using Pars test kits. The concentration of MDA in serum samples was evaluated by spectrophotometric method and based on the reaction of thiobarbituric acid. Nitric oxide levels were measured in samples by Gress method. Results: Serum MDA and hs-CRP levels were significantly increased in CAD patients compared to control group. In either case, the enzymatic activities of SOD and GPX erythrocyte and TAC levels were significantly reduced in patients. In the CAD group, total cholesterol, triglyceride and LDL-C levels were significantly higher and HDL-C levels were significantly lower than the control group. We found low concentrations of NO in the patient group compared with the healthy group (p<0. 05). Conclusion: The risk factors such as Inflammatory factors and oxidative stress in Coronary Artery Disease diabetic and Non-Smoker cases can also contribute to the development and progression of atherosclerosis, and it seems that low levels of NO and antioxidant markers can be seen in these patients as Other risk factors for the progression of Coronary Artery Disease.

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APA: Copy

KHAKI KHATIBI, FATEMEH. (2020). Relationship between serum levels of oxidants, antioxidants, inflammatory factor and nitric oxide in diabetic and non-smoker coronary artery disease patients. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, 42(2 ), 152-159. SID. https://sid.ir/paper/400985/en

Vancouver: Copy

KHAKI KHATIBI FATEMEH. Relationship between serum levels of oxidants, antioxidants, inflammatory factor and nitric oxide in diabetic and non-smoker coronary artery disease patients. MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;42(2 ):152-159. Available from: https://sid.ir/paper/400985/en

IEEE: Copy

FATEMEH KHAKI KHATIBI, “Relationship between serum levels of oxidants, antioxidants, inflammatory factor and nitric oxide in diabetic and non-smoker coronary artery disease patients,” MEDICAL JOURNAL OF TABRIZ UNIVERSITY OF MEDICAL SCIENCES, vol. 42, no. 2 , pp. 152–159, 2020, [Online]. Available: https://sid.ir/paper/400985/en

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