COMPARING THE EFFECT OF TREATMENT WITH INSULIN ALONE VERSUS INSULIN PLUS SULFONYLUREA IN TYPE 2 DIABETIC PATIENTS

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HASHEMIPOUR S.; POURMOHAMMAD S.; GHANEI L.; ESMAILZADEHHA N.; JAVADI A.

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Journal: Journal of Inflammatory Diseases Year:2013 | Volume:17 | Issue:2 (67) Page(s): 4-10

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Title

COMPARING THE EFFECT OF TREATMENT WITH INSULIN ALONE VERSUS INSULIN PLUS SULFONYLUREA IN TYPE 2 DIABETIC PATIENTS

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Keywords

DIABETES MELLITUS TYPE 2Q2

INSULINQ2

SULFONYLUREAQ3

Abstract

Background: INSULIN is administered for glycemic control in type 2 diabetic patients with secondary failure to oral antidiabetic drugs. Achieving good glycemic control requires a long time with relatively high INSULIN dose.Objective: The aim of this study was to compare the effect of treatment with INSULIN alone versus INSULIN plus SULFONYLUREA in type 2 diabetic patients.Methods: In this randomized clinical trial, 45 patients with secondary failure to oral antidiabetic drugs who referred to Bou-Ali hospital during 2009-2010, were randomly allocated into two groups of INSULIN alone and INSULIN plus SULFONYLUREA. Fasting and postprandial blood sugar, INSULIN dose, and weight gain were measured monthly up to 3 months. Data were analyzed by T-test and Chisquare test.Findings: At the end of the first and the third month of the treatment, mean fasting blood sugar was 146.3 ±21.1mg/dl and 126.9±10.2 mg/dl in combination therapy group and was 166.1±28.7 mg/dl and 144.5±20.9 mg/dl in INSULIN alone group, respectively (P=0.01 and P=0.001, respectively (P=0.01 and P=0.001, respectively. Mean postprandial blood sugar in combination group was lower than INSULIN alone group at the end of the third month(P=0.009). The difference in mean INSULIN dose between 2 groups was statistically significant at the end of the third month (P<0.001).Conclusion: With regard to the results, combination therapy with INSULIN plus SULFONYLUREA versus INSULIN alone would result in faster improvement of glycemic control and lower daily INSULIN dose.

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APA: Copy

HASHEMIPOUR, S., POURMOHAMMAD, S., GHANEI, L., ESMAILZADEHHA, N., & JAVADI, A.. (2013). COMPARING THE EFFECT OF TREATMENT WITH INSULIN ALONE VERSUS INSULIN PLUS SULFONYLUREA IN TYPE 2 DIABETIC PATIENTS. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 17(2 (67)), 4-10. SID. https://sid.ir/paper/402898/en

Vancouver: Copy

HASHEMIPOUR S., POURMOHAMMAD S., GHANEI L., ESMAILZADEHHA N., JAVADI A.. COMPARING THE EFFECT OF TREATMENT WITH INSULIN ALONE VERSUS INSULIN PLUS SULFONYLUREA IN TYPE 2 DIABETIC PATIENTS. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2013;17(2 (67)):4-10. Available from: https://sid.ir/paper/402898/en

IEEE: Copy

S. HASHEMIPOUR, S. POURMOHAMMAD, L. GHANEI, N. ESMAILZADEHHA, and A. JAVADI, “COMPARING THE EFFECT OF TREATMENT WITH INSULIN ALONE VERSUS INSULIN PLUS SULFONYLUREA IN TYPE 2 DIABETIC PATIENTS,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 17, no. 2 (67), pp. 4–10, 2013, [Online]. Available: https://sid.ir/paper/402898/en

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