THE PROTECTIVE EFFECT OF ASCORBIC ACID ON LEARNING AND MEMORY DEFICIT IN KAINATE-EPILEPTIC RAT

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KIASALARI ZAHRA; KHALILI MOHSEN; ROGHANI MEHRDAD; ALIMORADI VAHIDE

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Journal: DANESHVAR MEDICINE Year:2014 | Volume:21 | Issue:110 Page(s): 0-0

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Title

THE PROTECTIVE EFFECT OF ASCORBIC ACID ON LEARNING AND MEMORY DEFICIT IN KAINATE-EPILEPTIC RAT

Author(s)

KIASALARI ZAHRA | KHALILI MOHSEN | ROGHANI MEHRDAD | ALIMORADI VAHIDE | Issue Writer Certificate

Keywords

ASCORBIC ACIDQ3

TEMPORAL LOBE EPILEPSYQ2

SEIZUREQ3

MEMORY AND LEARNINGQ2

Abstract

Background and Objective: Epileptic SEIZUREs lead to a problem in learning and memory. In view of the protective effect of ASCORBIC ACID (vitamin C), the aim of this study was to investigate the effect of this substance on impairment of learning and memory in an experimental model of TEMPORAL LOBE EPILEPSY in kainate-epileptic rat.Materials and Methods: In this experimental study, rats were divided into four groups: sham, positive control, epileptic, and epileptic group receiving the ASCORBIC ACID. Kainic acid was used for induction of epilepsy. ASCORBIC ACID was injected intraperitoneally at a dose of 100 mg/kg/day from one week before surgery. Initial and step through latencies in the passive avoidance test and alternation behavior percentage in Y maze were also determined.Results: Pretreatment with vitamin C does not significantly decrease SEIZURE behavior compared with epileptic group. Regarding initial latency there was no statistically significant difference between groups. Step through latency in vitamin C pretreated group has no significant change versus epileptic group. Alternation behavior percentage in vitamin C pretreated epileptic group was significantly greater than epileptic group (p<0.05).Conclusion: Although pretreatment with vitamin C does not affect the ability to store and recall in passive avoidance test, but could cause an improvement in spatial memory.

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APA: Copy

KIASALARI, ZAHRA, KHALILI, MOHSEN, ROGHANI, MEHRDAD, & ALIMORADI, VAHIDE. (2014). THE PROTECTIVE EFFECT OF ASCORBIC ACID ON LEARNING AND MEMORY DEFICIT IN KAINATE-EPILEPTIC RAT. DANESHVAR MEDICINE, 21(110), 0-0. SID. https://sid.ir/paper/403981/en

Vancouver: Copy

KIASALARI ZAHRA, KHALILI MOHSEN, ROGHANI MEHRDAD, ALIMORADI VAHIDE. THE PROTECTIVE EFFECT OF ASCORBIC ACID ON LEARNING AND MEMORY DEFICIT IN KAINATE-EPILEPTIC RAT. DANESHVAR MEDICINE[Internet]. 2014;21(110):0-0. Available from: https://sid.ir/paper/403981/en

IEEE: Copy

ZAHRA KIASALARI, MOHSEN KHALILI, MEHRDAD ROGHANI, and VAHIDE ALIMORADI, “THE PROTECTIVE EFFECT OF ASCORBIC ACID ON LEARNING AND MEMORY DEFICIT IN KAINATE-EPILEPTIC RAT,” DANESHVAR MEDICINE, vol. 21, no. 110, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/403981/en

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