ANTIDEPRESSANT EFFECT OF AQUEOUS AND HYDROALCOHOLIC EXTRACTS OF LAVANDULA OFFICINALIS IN FORCED SWIM TEST AND TAIL SUSPENSION TEST IN MALE MICE

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ABBASI MALEKI S.; BEKHRADI R.; ASGHARPANAH J.; ABBASI MALEKI F.; MALEKI AHANGARI N.

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Journal: ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ) Year:2013 | Volume:16 | Issue:9 (78) Page(s): 0-0

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Title

ANTIDEPRESSANT EFFECT OF AQUEOUS AND HYDROALCOHOLIC EXTRACTS OF LAVANDULA OFFICINALIS IN FORCED SWIM TEST AND TAIL SUSPENSION TEST IN MALE MICE

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Keywords

LAVANDULAQ2

MICEQ2

PLANT EXTRACTSQ2

TAIL SUSPENSIONQ2

Abstract

Background: LAVANDULA officinalis has anti-anxiety and sedative properties. In the present study, the antidepressant effect of aqueous and hydroalcoholic extracts of LAVANDULA officinalis was investigated in forced swim test (FST) and TAIL SUSPENSION test (TST) in male MICE.Material and Methods: In this experimental study, 72 male MICE were randomly divided into 9 groups of 8 MICE. Negative and positive control groups received normal saline (10 ml/kg), fluoxetine (20mg/kg) and imipramine (30mg/kg) respectively and treatment groups received extracts of LAVANDULA officinalis (100, 200 and 400 mg/kg). Immobility, swimming and climbing behaviors were recorded within 6 minutes.Results: LAVANDULA officinalis extracts (except the aqueous extract at a dose of 100mg/kg in FST) compared to control group significantly and dose-dependently reduced the duration of immobility time in both of tests (p<0.001). These extracts (except the aqueous extract at a dose of 100mg/kg in FST) significantly and dose-dependently increased swimming time (p<0.001) without significant change of climbing time.Conclusion: LAVANDULA officinalis has considerable antidepressant effect and has similar effects to fluoxetine.

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APA: Copy

ABBASI MALEKI, S., BEKHRADI, R., ASGHARPANAH, J., ABBASI MALEKI, F., & MALEKI AHANGARI, N.. (2013). ANTIDEPRESSANT EFFECT OF AQUEOUS AND HYDROALCOHOLIC EXTRACTS OF LAVANDULA OFFICINALIS IN FORCED SWIM TEST AND TAIL SUSPENSION TEST IN MALE MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 16(9 (78)), 0-0. SID. https://sid.ir/paper/404038/en

Vancouver: Copy

ABBASI MALEKI S., BEKHRADI R., ASGHARPANAH J., ABBASI MALEKI F., MALEKI AHANGARI N.. ANTIDEPRESSANT EFFECT OF AQUEOUS AND HYDROALCOHOLIC EXTRACTS OF LAVANDULA OFFICINALIS IN FORCED SWIM TEST AND TAIL SUSPENSION TEST IN MALE MICE. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2013;16(9 (78)):0-0. Available from: https://sid.ir/paper/404038/en

IEEE: Copy

S. ABBASI MALEKI, R. BEKHRADI, J. ASGHARPANAH, F. ABBASI MALEKI, and N. MALEKI AHANGARI, “ANTIDEPRESSANT EFFECT OF AQUEOUS AND HYDROALCOHOLIC EXTRACTS OF LAVANDULA OFFICINALIS IN FORCED SWIM TEST AND TAIL SUSPENSION TEST IN MALE MICE,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 16, no. 9 (78), pp. 0–0, 2013, [Online]. Available: https://sid.ir/paper/404038/en

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