COMPARING THE COMBINED EFFECT OF LETROZOLE AND CLOMIPHENE REGIMEN PLUS GONADOTROPINS ON PREGNANCY RATE IN CLOMIPHENE RESISTANT-POLYCYSTIC OVARIAN SYNDROME

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FOROUZANFARD F.; PEZHMANMANESH M.; MAHDIAN M.; MOUSAVI SEYED GHOLAM ABAS

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Feyz Medical Sciences Journal Year:2010 | Volume:14 | Issue:1 (SERIAL 53) Page(s): 12-17

Download Full-Text

Persian Verion

View:

1,181

Download:

Cites:

Information Journal Paper

Title

COMPARING THE COMBINED EFFECT OF LETROZOLE AND CLOMIPHENE REGIMEN PLUS GONADOTROPINS ON PREGNANCY RATE IN CLOMIPHENE RESISTANT-POLYCYSTIC OVARIAN SYNDROME

Author(s)

FOROUZANFARD F. | PEZHMANMANESH M. | MAHDIAN M. | MOUSAVI SEYED GHOLAM ABAS | Issue Writer Certificate

Keywords

INFERTILITYQ2

POLYCYSTIC OVARY SYNDROMEQ2

OVULATION INDUCTIONQ3

LETROZOLEQ2

CLOMIPHENEQ3

Abstract

Background: Although CLOMIPHENE citrate is the first line in OVULATION INDUCTION in anovulatory infertile women, but some of polycystic ovarian syndrome (PCOS) patients are CLOMIPHENE-resistant. This study was carried out to compare the combined effect of LETROZOLE and CLOMIPHENE with gonadotropins on pregnancy rate in CLOMIPHENE-resistant PCOS patients. Materials and Methods: This clinical trial study was carried out on 120 CLOMIPHENE-resistant PCOS patients. The patients were randomly divided into two groups: group 1 received CLOMIPHENE (100 mg/day) and group 2 received LETROZOLE (5 mg/day) on the 3–7th days of menstrual cycle. Both groups received (150 IU/im) HMG on the 5–8th days of menstrual cycle. On 10-11th days of menstrual cycle, transvaginal sonography was performed to determine endometrial thickness, dominant follicle number and increase HMG dose, if required. HCG at a dose of 5000 IU was administered when at least one mature follicle was observed. b-HCG level was evaluated 2 weeks after HCG administration. The two groups were compared for mature follicles numbers, endometrial thickness, gonadotropin consumption and pregnancy rate. Chi–square, Kolomogrov–Smirnov, t-test, Levene, Mann-Whitney tests were used to analyze data.Results: Although the pregnancy rate in LETROZOLE group was higher than in the CLOMIPHENE one, the difference was not significant (36.7% vs 33.3%, P=0.702). The mean endometrial thickness in LETROZOLE and CLOMIPHENE group was 7.47 mm and 7.49 mm, respectively (P=0.685). In LETROZOLE and CLOMIPHENE group the mean of dominant follicles numbers was 2.18 and 2.83, respectively (P=0.087) while the gonadotropin level mean in both groups was 6.78 (P=0.941).Conclusion: In CLOMIPHENE resistant PCOS patients, similar to CLOMIPHENE, LETROZOLE in combined regimens with gonadotropin can be effective for the induction of ovulation.

Cites

No record.

References

No record.

Cite

APA: Copy

FOROUZANFARD, F., PEZHMANMANESH, M., MAHDIAN, M., & MOUSAVI, SEYED GHOLAM ABAS. (2010). COMPARING THE COMBINED EFFECT OF LETROZOLE AND CLOMIPHENE REGIMEN PLUS GONADOTROPINS ON PREGNANCY RATE IN CLOMIPHENE RESISTANT-POLYCYSTIC OVARIAN SYNDROME. FEYZ, 14(1 (SERIAL 53)), 12-17. SID. https://sid.ir/paper/40419/en

Vancouver: Copy

FOROUZANFARD F., PEZHMANMANESH M., MAHDIAN M., MOUSAVI SEYED GHOLAM ABAS. COMPARING THE COMBINED EFFECT OF LETROZOLE AND CLOMIPHENE REGIMEN PLUS GONADOTROPINS ON PREGNANCY RATE IN CLOMIPHENE RESISTANT-POLYCYSTIC OVARIAN SYNDROME. FEYZ[Internet]. 2010;14(1 (SERIAL 53)):12-17. Available from: https://sid.ir/paper/40419/en

IEEE: Copy

F. FOROUZANFARD, M. PEZHMANMANESH, M. MAHDIAN, and SEYED GHOLAM ABAS MOUSAVI, “COMPARING THE COMBINED EFFECT OF LETROZOLE AND CLOMIPHENE REGIMEN PLUS GONADOTROPINS ON PREGNANCY RATE IN CLOMIPHENE RESISTANT-POLYCYSTIC OVARIAN SYNDROME,” FEYZ, vol. 14, no. 1 (SERIAL 53), pp. 12–17, 2010, [Online]. Available: https://sid.ir/paper/40419/en

Related Journal Papers