THE EFFICACY OF PYRIDOXINE (VIT B6) IN THE TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY

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KHADEM N.; HOSSEINZADEH H.; HAFIZI L.; AZARHOSHANGI P.

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Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2002 | Volume:5 | Issue:2 Page(s): 34-41

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Title

THE EFFICACY OF PYRIDOXINE (VIT B6) IN THE TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY

Author(s)

KHADEM N. | HOSSEINZADEH H. | HAFIZI L. | AZARHOSHANGI P. | Issue Writer Certificate

Keywords

NAUSEA AND VOMITING OF PREGNANCYQ2

HYPEREMESISQ4

PYRIDOXINEQ2

VIT B6Q3

METOCLOPRAMIDEQ3

PLACEBOQ4

CLINICAL EVALUATIONQ4

Abstract

Objective: NAUSEA AND VOMITING OF PREGNANCY are the most common complaints during the first half of pregnancy, and about 80% of pregnant women experience them. We studied the clinical effect of PYRIDOXINE on nausea and vomiting in pregnancy, and compared it with METOCLOPRAMIDE and PLACEBO.Materials and Method: This study was a randomized, prospective and double-blind PLACEBO controlled clinical trial. The subjects were 77 pregnant women with complaining nausea and vomiting presenting to three health and medical centers of Mashhad (Imam Reza Hospital, Shahid Ghodsi and Azadshahr 1 Health Centers) from September 1999 to November, 2000.Result: Patients were randomly divided into three groups: case (pyridoxine hydrochloride); positive control (metoclopramide) and PLACEBO (starch powder). The severity and frequency of nausea and vomiting were recorded by patients, and statistical analysis employed were the Paired T test, Tukey, ANOVA and Fisher. (p. value ? 0.05 was considered as significant differences). From 77 pregnant women in this study, 28 patients received PYRIDOXINE, 25 received PLACEBO and 24 received METOCLOPRAMIDE. PYRIDOXINE reduced the severity of nausea and vomiting, but there was not a significant difference with PLACEBO. Also prydoxine did not reduce the severity and frequency of nausea and vomiting. In contrast, in METOCLOPRAMIDE group either the severity or the frequency of nausea and vomiting were reduced.Conclusion: In this study, the efficacy of PYRIDOXINE and PLACEBO on NAUSEA AND VOMITING OF PREGNANCY was the same. Because these symptoms were improved with PLACEBO we can prescribe PYRIDOXINE or any other PLACEBO for these patients at the first step unless disease has a serious risk for mother and fetus.

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APA: Copy

KHADEM, N., HOSSEINZADEH, H., HAFIZI, L., & AZARHOSHANGI, P.. (2002). THE EFFICACY OF PYRIDOXINE (VIT B6) IN THE TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 5(2), 34-41. SID. https://sid.ir/paper/404562/en

Vancouver: Copy

KHADEM N., HOSSEINZADEH H., HAFIZI L., AZARHOSHANGI P.. THE EFFICACY OF PYRIDOXINE (VIT B6) IN THE TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2002;5(2):34-41. Available from: https://sid.ir/paper/404562/en

IEEE: Copy

N. KHADEM, H. HOSSEINZADEH, L. HAFIZI, and P. AZARHOSHANGI, “THE EFFICACY OF PYRIDOXINE (VIT B6) IN THE TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 5, no. 2, pp. 34–41, 2002, [Online]. Available: https://sid.ir/paper/404562/en

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