EFFECT OF STRESS RESULTING FROM INDEPENDENT AND SYNERGIC MORPHINE USE ON SERUM CORTISOL LEVEL IN RAT

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RADAHMADI MARYAM; AMINI MASOUD; FESHARAKI M.; SHARIFI M.R.

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Paper Information

Journal: Feyz Medical Sciences Journal Year:2005 | Volume:9 | Issue:1 (Serial 33) Page(s): 26-29

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Title

EFFECT OF STRESS RESULTING FROM INDEPENDENT AND SYNERGIC MORPHINE USE ON SERUM CORTISOL LEVEL IN RAT

Author(s)

RADAHMADI MARYAM | AMINI MASOUD | FESHARAKI M. | SHARIFI M.R. | Issue Writer Certificate

Keywords

MORPHINEQ2

CARBOHYDRATEQ2

CORTISOLQ4

Abstract

Background: In this study effects of stress resulted from using independent and co- administration MORPHINE and CARBOHYDRATE on serum CORTISOL levels in rat were investigated to determine the possible causal link between MORPHINE, CARBOHYDRATE and serum CORTISOL level. Materials and Methods: This experimental study was performed on 24 male Wistar rats (200-250 gr) divided to 3 groups (n=8). MORPHINE dependency was induced by increasing doses of MORPHINE through intraperitioneal (IP) injection. Animals were injected 10, 20, 30, 40, 50, 60 mg/kg MORPHINE sulfate on days 1, 2, 3, 4, 5, 6 respectively and dose of 60 mg/kg was repeated for 20 extra days (Mo group). Another group of animals received the same dose of MORPHINE plus l gr/kg glucose per day through intraperitoneal (IP) injection (Mo+Glu group). Duration of experiment was 26 days. Results: Significant increase in serum CORTISOL level was observed after long-term use of both MORPHINE and co-administration of MORPHINE and CARBOHYDRATE. However, this increase was higher in Mo+Glu group than MORPHINE group. (16.57% vs. 11.55%, P<0.05) Conclusion: long-term use of MORPHINE, with or without CARBOHYDRATE, may increase serum CORTISOL level.

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APA: Copy

RADAHMADI, MARYAM, AMINI, MASOUD, FESHARAKI, M., & SHARIFI, M.R.. (2005). EFFECT OF STRESS RESULTING FROM INDEPENDENT AND SYNERGIC MORPHINE USE ON SERUM CORTISOL LEVEL IN RAT. FEYZ, 9(1 (Serial 33)), 26-29. SID. https://sid.ir/paper/40520/en

Vancouver: Copy

RADAHMADI MARYAM, AMINI MASOUD, FESHARAKI M., SHARIFI M.R.. EFFECT OF STRESS RESULTING FROM INDEPENDENT AND SYNERGIC MORPHINE USE ON SERUM CORTISOL LEVEL IN RAT. FEYZ[Internet]. 2005;9(1 (Serial 33)):26-29. Available from: https://sid.ir/paper/40520/en

IEEE: Copy

MARYAM RADAHMADI, MASOUD AMINI, M. FESHARAKI, and M.R. SHARIFI, “EFFECT OF STRESS RESULTING FROM INDEPENDENT AND SYNERGIC MORPHINE USE ON SERUM CORTISOL LEVEL IN RAT,” FEYZ, vol. 9, no. 1 (Serial 33), pp. 26–29, 2005, [Online]. Available: https://sid.ir/paper/40520/en

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