THE PREVALENCE OF FXIII VAL34LEU POLYMORPHISM IN THROMBOTIC PATIENTS REFERRED TO COAGULATION UNIT OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (IBTO)

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SAJADI S.M.M.; SAMIEI SH.; KHEYR ANDISH MARYAM; KAVARI M.; ABD ELAHI MARYAM; TOUTIAN S.; TABATABAEI SEYED MOHAMMAD REZA; MESHKANI R.

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Title

THE PREVALENCE OF FXIII VAL34LEU POLYMORPHISM IN THROMBOTIC PATIENTS REFERRED TO COAGULATION UNIT OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (IBTO)

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Keywords

FXIIIQ3

PCR-RFLPQ3

POLYMORPHISMQ3

THROMBOSISQ3

VAL34LEUQ3

Abstract

Background: Coagulation factor XIII is a transglutaminase with a tetrameric structure which consists of two identical pre enzyme subunits (FXIIIA) and two carrier protein subunits (FXIIIB). FXIII VAL34LEU POLYMORPHISM has a high prevalence in Caucasians. The prevalence of FXIII VAL34LEU POLYMORPHISM in Iranian patients was investigated in this study by PCR-RFLP method.Materials and Methods: In this descriptive study blood samples of 213 patients referred to the central laboratory of IBTO were assessed by DNA extraction and polymerase chain reaction (PCR). Then the genotypes of this POLYMORPHISM were identified by RFLP method in the presence of restricted enzyme. Data analyzed by SPSS 11.5 software and X2 Test.Results: The prevalence of VAL34LEU POLYMORPHISM was 24.4% (22.06% heterozygote and 2.34% homozygote and 13.07% of Leu allele frequency). No relationship was seen between the POLYMORPHISM and sex.Conclusion: The high prevalence of FXIII VAL34LEU POLYMORPHISM in Iranian thrombotic patients in comparison with reports from other Asian countries confirms the ethnic heterogenecity of this POLYMORPHISM which is not influenced by sex.

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APA: Copy

SAJADI, S.M.M., SAMIEI, SH., KHEYR ANDISH, MARYAM, KAVARI, M., ABD ELAHI, MARYAM, TOUTIAN, S., TABATABAEI, SEYED MOHAMMAD REZA, & MESHKANI, R.. (2008). THE PREVALENCE OF FXIII VAL34LEU POLYMORPHISM IN THROMBOTIC PATIENTS REFERRED TO COAGULATION UNIT OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (IBTO). FEYZ, 12(1 (SERIAL 45)), 76-80. SID. https://sid.ir/paper/40654/en

Vancouver: Copy

SAJADI S.M.M., SAMIEI SH., KHEYR ANDISH MARYAM, KAVARI M., ABD ELAHI MARYAM, TOUTIAN S., TABATABAEI SEYED MOHAMMAD REZA, MESHKANI R.. THE PREVALENCE OF FXIII VAL34LEU POLYMORPHISM IN THROMBOTIC PATIENTS REFERRED TO COAGULATION UNIT OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (IBTO). FEYZ[Internet]. 2008;12(1 (SERIAL 45)):76-80. Available from: https://sid.ir/paper/40654/en

IEEE: Copy

S.M.M. SAJADI, SH. SAMIEI, MARYAM KHEYR ANDISH, M. KAVARI, MARYAM ABD ELAHI, S. TOUTIAN, SEYED MOHAMMAD REZA TABATABAEI, and R. MESHKANI, “THE PREVALENCE OF FXIII VAL34LEU POLYMORPHISM IN THROMBOTIC PATIENTS REFERRED TO COAGULATION UNIT OF IRANIAN BLOOD TRANSFUSION ORGANIZATION (IBTO),” FEYZ, vol. 12, no. 1 (SERIAL 45), pp. 76–80, 2008, [Online]. Available: https://sid.ir/paper/40654/en

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