Determination of the frequency and response to treatment of ocular lesions in children with various types of intrauterine infections (cytomegalovirus and toxoplasmosis): brief report

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NOORBAKHSH SAMILEH; EHSANIPOUR FAHIMEH; Masalegooyan Niusha

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Tehran University Medical Journal Year:2019 | Volume:77 | Issue:9 Page(s): 595-599

Download Full-Text

Persian Verion

View:

291

Download:

Cites:

Information Journal Paper

Title

Determination of the frequency and response to treatment of ocular lesions in children with various types of intrauterine infections (cytomegalovirus and toxoplasmosis): brief report

Author(s)

NOORBAKHSH SAMILEH | EHSANIPOUR FAHIMEH | Masalegooyan Niusha | Issue Writer Certificate

Keywords

cytomegalovirusQ1

infantsQ2

infectionsQ1

ocular lesionsQ1

toxoplasmosisQ3

uterusQ3

Abstract

Background: Intrauterine infections (TORCH) lead to the involvement of various organs of the body of the fetus, including the eye. The aim of this study was to determine the frequency and clinical response of eye lesions to specific drugs, in infants with confirmed TORCH induced ocular lesions. Methods: This historical cohort study from 2011 to 2017, had done in Pediatrics and Ophthalmology Department of Rasoul Akram Hospital, Tehran, Iran. Cases included; 78 infants with confirmed intrauterine infection (TORCH) with ophthalmologic disorders (glaucoma, cataract, and retinitis), 3 cases died (without any treatment). The cases with incomplete diagnosis, no treatment or without follow-up excluded from study. Out of 74 children with confirmed TORCH induced ophthalmologic disorders, finally 37 children (25 cytomegalovirus, 12 toxoplasma) were treated with specific drugs, and clinical response to treatment was followed-up to 1 year by ophthalmologic examination. Results: From 12 cases with ophthalmologic disorders due to congenital toxoplasmosis, 5 cases had full treatment, 4 cases had complete response. One case had not any improvement. From 25 cases with congenital cytomegalovirus (CMV), 18 patients continued treatment, 9 cases with complete clinical response, 9 cases had not response to antiviral treatment, indeed most non responder cases had central nervous system involvement from birth. The best response observed in CMV infected cases accompanied with sensory hearing loss (without CNS involvement). Conclusion: Good clinical response of ophthalmic diseases in 80% of congenital toxoplasma; and 50% of congenital cytomegalovirus infected cases. Probably with initial diagnosis and rapid treatment of cases with TORCH induced ophthalmic disorders (especially cases without CNS involvement) it would lead to stopping ocular lesions.

Cites

No record.

References

No record.

Cite

APA: Copy

NOORBAKHSH, SAMILEH, EHSANIPOUR, FAHIMEH, & Masalegooyan, Niusha. (2019). Determination of the frequency and response to treatment of ocular lesions in children with various types of intrauterine infections (cytomegalovirus and toxoplasmosis): brief report. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 77(9 ), 595-599. SID. https://sid.ir/paper/406659/en

Vancouver: Copy

NOORBAKHSH SAMILEH, EHSANIPOUR FAHIMEH, Masalegooyan Niusha. Determination of the frequency and response to treatment of ocular lesions in children with various types of intrauterine infections (cytomegalovirus and toxoplasmosis): brief report. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2019;77(9 ):595-599. Available from: https://sid.ir/paper/406659/en

IEEE: Copy

SAMILEH NOORBAKHSH, FAHIMEH EHSANIPOUR, and Niusha Masalegooyan, “Determination of the frequency and response to treatment of ocular lesions in children with various types of intrauterine infections (cytomegalovirus and toxoplasmosis): brief report,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 77, no. 9 , pp. 595–599, 2019, [Online]. Available: https://sid.ir/paper/406659/en

Related Journal Papers