EFFECT OF POST-TRAINING FLUMAZENIL ADMINISTRATION ON BACLOFEN-INDUCED AMNESIA IN PASSIVE AVOIDANCE LEARNING

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SARIHI A.; MOHAMMADI Z.; MIRAZI N.; KOMAKI A.

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Journal: Feyz Medical Sciences Journal Year:2014 | Volume:18 | Issue:2 Page(s): 111-115

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Title

EFFECT OF POST-TRAINING FLUMAZENIL ADMINISTRATION ON BACLOFEN-INDUCED AMNESIA IN PASSIVE AVOIDANCE LEARNING

Author(s)

SARIHI A. | MOHAMMADI Z. | MIRAZI N. | KOMAKI A. | Issue Writer Certificate

Keywords

AVOIDANCE MEMORYQ2

BACLOFENQ2

FLUMAZENILQ1

RATQ2

Abstract

Background: BACLOFEN as a GABA-B receptor agonist and FLUMAZENIL as a benzodiazepine receptor antagonist facilitate chloride influx via GABA receptors. The aim of this study was to investigate the effect of FLUMAZENIL on BACLOFEN-induced amnesia in passive avoidance learning in male RATs.Materials and Methods: In this study, 49 male RATs (200-250 gr) were randomly divided into 7 groups (n=7): non-shocked, shocked, FLUMAZENIL (0.5mg/kg, i.p.), BACLOFEN (10 mg/kg, I.P.), and three groups which received BACLOFEN together with FLUMAZENIL at 5, 90 and 360 min post-training. Animals were examined by shuttle box for avoidance learning and retrieval test was done 48 h after learning. The step through latency and passive avoidance response including time in dark chamber and number of entrance were recorded and analyzed.Results: The amnesic effect of BACLOFEN was confirmed by the results of our study.Flumazenil alone had no effect on passive AVOIDANCE MEMORY, although 90 min after training it inhibited the BACLOFEN-induced amnesia.Conclusion: It seems that FLUMAZENIL is able to antagonize the inhibitory effect of BACLOFEN.It can be concluded that FLUMAZENIL in the elevated concentrations can affect GABA-B receptors and have long lasting effect on memory retention.

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APA: Copy

SARIHI, A., MOHAMMADI, Z., MIRAZI, N., & KOMAKI, A.. (2014). EFFECT OF POST-TRAINING FLUMAZENIL ADMINISTRATION ON BACLOFEN-INDUCED AMNESIA IN PASSIVE AVOIDANCE LEARNING. FEYZ, 18(2), 111-115. SID. https://sid.ir/paper/40780/en

Vancouver: Copy

SARIHI A., MOHAMMADI Z., MIRAZI N., KOMAKI A.. EFFECT OF POST-TRAINING FLUMAZENIL ADMINISTRATION ON BACLOFEN-INDUCED AMNESIA IN PASSIVE AVOIDANCE LEARNING. FEYZ[Internet]. 2014;18(2):111-115. Available from: https://sid.ir/paper/40780/en

IEEE: Copy

A. SARIHI, Z. MOHAMMADI, N. MIRAZI, and A. KOMAKI, “EFFECT OF POST-TRAINING FLUMAZENIL ADMINISTRATION ON BACLOFEN-INDUCED AMNESIA IN PASSIVE AVOIDANCE LEARNING,” FEYZ, vol. 18, no. 2, pp. 111–115, 2014, [Online]. Available: https://sid.ir/paper/40780/en

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