The Long-Term Effect of High Fat Diet and Regular Aerobic Exercise Training on Gene Expression of Isoforms of Mitochondrial Creatine Kinase (Ckmt1, 2) in White Adipose Tissue of Mice: An Experimental Study

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Daneshyar S.; Pouyandeh Ravan A.; KHOSRAVI A.; FOROUTAN Y.

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2020 | Volume:19 | Issue:6 Page(s): 619-632

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Title

The Long-Term Effect of High Fat Diet and Regular Aerobic Exercise Training on Gene Expression of Isoforms of Mitochondrial Creatine Kinase (Ckmt1, 2) in White Adipose Tissue of Mice: An Experimental Study

Author(s)

Daneshyar S. | Pouyandeh Ravan A. | KHOSRAVI A. | FOROUTAN Y. | Issue Writer Certificate

Keywords

ObesityQ2

High fat dietQ1

ThermogenesisQ1

White adipose tissueQ1

C57BL/6 miceQ2

Abstract

Background and Objectives: Mitochondrial creatine kinase involves in UCP-independent Thermogenesis. It isthought that the agent can be affected by nutrition and exercise. The aim of this study was to investigate the longterm effect of High fat diet and regular aerobic exercise training on gene expression of mitochondrial creatine kinase 1 (CKmt1) and mitochondrial creatine kinase 2 (CKmt2) in White adipose tissue of mice. Materials and Methods: In this experimental study, 28 male C57BL/6 mice were divide into four groups including control (n=7), High fat diet (HFD) (n=7), exercise training (ET) (n=7) and HFD-exercise training (HFD-ET) (n=7). The subjects of the HFD groups were fed a high-fat diet (fat: %40) for a period of 12 weeks. The subjects of the training groups underwent continuous training for six weeks. The Real Time– PCR method was used to measure the expression levels of the Ckmt1and Ckmt2 genes. The two-way ANOVA was applied to analyze data. Results: Data showed that the HFD (p=0. 324) and ET (p=0. 136) did not significantly affect the gene expression level of CKmt1. However, the gene expression level of CKmt2 was significantly decreased and increased by HFD and ET versus High fat diet group, respectively (p=0. 043; p=0. 001, respectively). Conclusion: The findings of this study indicated that the long term feeding of High fat diet and regular aerobic training could probably affect the non-shivering Thermogenesis at White adipose tissue by decreasing and increasing the expression of mitochondrial creatine kinase 2 (CKmt2), respectively.

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APA: Copy

Daneshyar, S., Pouyandeh Ravan, A., KHOSRAVI, A., & FOROUTAN, Y.. (2020). The Long-Term Effect of High Fat Diet and Regular Aerobic Exercise Training on Gene Expression of Isoforms of Mitochondrial Creatine Kinase (Ckmt1, 2) in White Adipose Tissue of Mice: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 19(6 ), 619-632. SID. https://sid.ir/paper/407886/en

Vancouver: Copy

Daneshyar S., Pouyandeh Ravan A., KHOSRAVI A., FOROUTAN Y.. The Long-Term Effect of High Fat Diet and Regular Aerobic Exercise Training on Gene Expression of Isoforms of Mitochondrial Creatine Kinase (Ckmt1, 2) in White Adipose Tissue of Mice: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2020;19(6 ):619-632. Available from: https://sid.ir/paper/407886/en

IEEE: Copy

S. Daneshyar, A. Pouyandeh Ravan, A. KHOSRAVI, and Y. FOROUTAN, “The Long-Term Effect of High Fat Diet and Regular Aerobic Exercise Training on Gene Expression of Isoforms of Mitochondrial Creatine Kinase (Ckmt1, 2) in White Adipose Tissue of Mice: An Experimental Study,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 19, no. 6 , pp. 619–632, 2020, [Online]. Available: https://sid.ir/paper/407886/en

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