Study of association betweenprs7975232 polymorphism in vitamin D receptor gene and periodontitis by Tetra Arms-PCR

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Siasi Torbati Elahm; Tavakkoli Nafiseh; AMINI KUMARSS

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Journal: Journal of Dental Medicine Year:2021 | Volume:33 | Issue:4 Page(s): 227-239

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Information Journal Paper

Title

Study of association betweenprs7975232 polymorphism in vitamin D receptor gene and periodontitis by Tetra Arms-PCR

Author(s)

Siasi Torbati Elahm | Tavakkoli Nafiseh | AMINI KUMARSS | Issue Writer Certificate

Keywords

Periodontitis diseaseQ2

Single nucleotide polymorphismQ1

Vitamin D receptorQ1

Abstract

Background and Aims: Periodontitis is an inflammatory multifactorial disease in oral tissues and many genetic reasons and environmental factors responsible. Vitamin D deficiency has been determined to be related to periodontal disease. This aim of this study was to investigate the association between rs7975232 polymorphism in Vitamin D receptor gene and periodontitis in 100 patients (as patient and control groups). Materials and Methods: Blood samples from 50 patients and 50 control groups were selected and DNA from the samples was extracted by the DNA extraction kit. Genotyping was used by Tetra arms-PCR method. The use of sequencing was confirmed by the Tetra arms-PCR genotyping results. Then, statistical analysis was performed using SPSS statistics 20 software and T-test. Results: Frequency of AA, AC, and CC Genotypes were 25 (50%), 14 (28%), and 11 (22%) in patients’ cases, and 26 (52%), 16 (32%) and 8 (16%) in controls, respectively. AA genotype was the highest genotype between the patient and control groups. Statistical analysis showed no significant association between this type of polymorphism and Periodontitis disease in the studied samples (P=0. 67). Conclusion: This finding showed there was not significant association between rs7975232 polymorphism in Vitamin D receptor gene and Periodontitis disease in the studied samples. To confirm the results of this study, further studies with large sample size and different types of population are recommended.

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APA: Copy

Siasi Torbati, Elahm, Tavakkoli, Nafiseh, & AMINI, KUMARSS. (2021). Study of association betweenprs7975232 polymorphism in vitamin D receptor gene and periodontitis by Tetra Arms-PCR. JOURNAL OF DENTAL MEDICINE, 33(4 ), 227-239. SID. https://sid.ir/paper/408564/en

Vancouver: Copy

Siasi Torbati Elahm, Tavakkoli Nafiseh, AMINI KUMARSS. Study of association betweenprs7975232 polymorphism in vitamin D receptor gene and periodontitis by Tetra Arms-PCR. JOURNAL OF DENTAL MEDICINE[Internet]. 2021;33(4 ):227-239. Available from: https://sid.ir/paper/408564/en

IEEE: Copy

Elahm Siasi Torbati, Nafiseh Tavakkoli, and KUMARSS AMINI, “Study of association betweenprs7975232 polymorphism in vitamin D receptor gene and periodontitis by Tetra Arms-PCR,” JOURNAL OF DENTAL MEDICINE, vol. 33, no. 4 , pp. 227–239, 2021, [Online]. Available: https://sid.ir/paper/408564/en

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