Effects of treadmill exercise and preconditioned bone marrow-derived mesenchymal stem cells transplantation on Aβ-induced neurotoxicity in male rats

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Abshenas Rokhsareh; ARTIMANI TAYEBE; AMIRI IRAJ; SHAHIDI SIAMAK; NAJAFI REZVAN; SOLEIMANI ASL SARA

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Journal: Koomesh Year:2020 | Volume:22 | Issue:2 (78) Page(s): 325-333

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Title

Effects of treadmill exercise and preconditioned bone marrow-derived mesenchymal stem cells transplantation on Aβ-induced neurotoxicity in male rats

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Keywords

ExerciseQ2

AmyloidQ2

Mesenchymal Stem cells;OxalylglycineQ2

AntioxidantQ1

ApoptosisQ1

Abstract

Introduction: Preconditioning of mesenchymal stem cells (MSCs) is a promising strategy to enhance the therapeutic properties of transplanted MSCs. In this study, we investigated the synergistic effects of treadmill Exercise and dimethyloxalylglycine (DMOG)-preconditioned stem cells in an Alzheimer’ s disease (AD) model. Materials and Methods: DMOG-treated MSCs were intravenously transplanted in the AD model and the rats went on treadmill Exercise for one month. Thusly, expression of bax, bcl-2, Nrf2, and NQO1 genes were assessed using real-time PCR. Results: Transplantation of DMOG-treated cells had greater effects on increasing Nrf-2 and NQ1 expression and reducing Apoptosis compared to non-treated cells. Ultimately, treadmill Exercises for one month along with the transplantation of DMOG-treated cells showed the highest neuroprotective effect. Conclusion: It seems that the transplantation of DMOG-treated cells beside Exercise may have protective effects in the AD model via an increase in Antioxidant capacity and a decrease in Apoptosis.

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APA: Copy

Abshenas, Rokhsareh, ARTIMANI, TAYEBE, AMIRI, IRAJ, SHAHIDI, SIAMAK, NAJAFI, REZVAN, & SOLEIMANI ASL, SARA. (2020). Effects of treadmill exercise and preconditioned bone marrow-derived mesenchymal stem cells transplantation on Aβ-induced neurotoxicity in male rats. KOOMESH, 22(2 (78) ), 325-333. SID. https://sid.ir/paper/409152/en

Vancouver: Copy

Abshenas Rokhsareh, ARTIMANI TAYEBE, AMIRI IRAJ, SHAHIDI SIAMAK, NAJAFI REZVAN, SOLEIMANI ASL SARA. Effects of treadmill exercise and preconditioned bone marrow-derived mesenchymal stem cells transplantation on Aβ-induced neurotoxicity in male rats. KOOMESH[Internet]. 2020;22(2 (78) ):325-333. Available from: https://sid.ir/paper/409152/en

IEEE: Copy

Rokhsareh Abshenas, TAYEBE ARTIMANI, IRAJ AMIRI, SIAMAK SHAHIDI, REZVAN NAJAFI, and SARA SOLEIMANI ASL, “Effects of treadmill exercise and preconditioned bone marrow-derived mesenchymal stem cells transplantation on Aβ-induced neurotoxicity in male rats,” KOOMESH, vol. 22, no. 2 (78) , pp. 325–333, 2020, [Online]. Available: https://sid.ir/paper/409152/en

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