EFFECT OF AQUEOUS EXTRACT OF FERULA ASSA-FOETIDA L. RESIN ON ANGIOGENESIS IN RAT AORTIC RING MODEL

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

EDALATMANESH M.A.; SADOUGHI S.D.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Feyz Medical Sciences Journal Year:2016 | Volume:20 | Issue:2 Page(s): 100-107

Download Full-Text

Persian Verion

View:

809

Download:

Cites:

Information Journal Paper

Title

EFFECT OF AQUEOUS EXTRACT OF FERULA ASSA-FOETIDA L. RESIN ON ANGIOGENESIS IN RAT AORTIC RING MODEL

Author(s)

EDALATMANESH M.A. | SADOUGHI S.D. | Issue Writer Certificate

Keywords

ANGIOGENESISQ2

FERULA ASSA-FOETIDA L.Q1

AORTIC RINGQ2

RATQ2

Abstract

Background: Besides embryogenesis, the ANGIOGENESIS is required for many physiological and pathological conditions (e.g. tumor growth). Various studies have shown the anti-proliferative and anti-cancer effects of Ferula assa-foetida (FF) resin. In the present study using a Wistar RAT aortic model the effect of aqueous extract of FF resin on the ANGIOGENESIS has been investigated.Materials and Methods: In this experimental study, Wistar RAT aorta was divided into strips (1 mm) and cultured in collagen matrixes. Following the observation of angiogenic sprouting on third day, the samples were classified into 4 groups (n=8 in each group): Control group, Sham-exposed group (treated with sterile distilled water) and Experimental groups 1 and 2 (treated with 100 and 200mg/ml of aqueous extract of FF resin, respectively). After 24 hours, the ANGIOGENESIS was assessed using the invert microscopy followed by the photography of all samples. The length and number of blood vessels were measured using Image J software.Results: The Mean for length (143.8±5.3) and number (51.2±7.3) of vessels in Control samples showed no significant difference compared to Sham-exposed samples (138.1±3.8) and (46.3±5.4), respectively. The Mean length and number of vessels in the Experimental groups 1 (81.5±4.5; 26.8±3.5) and 2 (35.9±4.3; 7.7±2.6) were significantly decreased in a dose-dependent manner compared to the Control group (P<0.05).Conclusion: The aqueous extract of FF resin dose-dependently inhibits the ANGIOGENESIS. Therefore, the use of FF resin can be effective in inhibiting the ANGIOGENESIS.

Cites

No record.

References

No record.

Cite

APA: Copy

EDALATMANESH, M.A., & SADOUGHI, S.D.. (2016). EFFECT OF AQUEOUS EXTRACT OF FERULA ASSA-FOETIDA L. RESIN ON ANGIOGENESIS IN RAT AORTIC RING MODEL. FEYZ, 20(2 ), 100-107. SID. https://sid.ir/paper/40932/en

Vancouver: Copy

EDALATMANESH M.A., SADOUGHI S.D.. EFFECT OF AQUEOUS EXTRACT OF FERULA ASSA-FOETIDA L. RESIN ON ANGIOGENESIS IN RAT AORTIC RING MODEL. FEYZ[Internet]. 2016;20(2 ):100-107. Available from: https://sid.ir/paper/40932/en

IEEE: Copy

M.A. EDALATMANESH, and S.D. SADOUGHI, “EFFECT OF AQUEOUS EXTRACT OF FERULA ASSA-FOETIDA L. RESIN ON ANGIOGENESIS IN RAT AORTIC RING MODEL,” FEYZ, vol. 20, no. 2 , pp. 100–107, 2016, [Online]. Available: https://sid.ir/paper/40932/en

Related Journal Papers