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Information Journal Paper

Title

One-Step Synthesis of Novel Heterocycles of Dihydroquinolone-Coumarin in the Presence of ZnBr2 Catalyst

Pages

  171-181

Abstract

 In view of the biological and pharmaceutical significance of Coumarin and 3, 4-Dihydroquinolone structures, such as anticancer, anticoagulation of blood vessels and anti-HIV activities, and advantageous of synthesis of hybrid molecules by the combination of known pharmacophores for the development of a diverse range of novel pharmaceutical agents as potent drugs with many improved properties, in this article, various novel tetra-and pentacyclic heterocycles of 3, 4-Dihydroquinolones annulated tetrahydropyranoCoumarin and α-pyrone were synthesized via domino Knoevenagel Hetero Diels-Alder reaction of N-acrylated anthranilaldehyde with 4-hydroxy-Coumarin and α-pyrone (4-hydroxy-6-methyl-2H-pyran-2-one) in the presence of 50 mol% ZnBr2 as a mild and low cost catalyst in refluxing acetic acid in one step. All products achieved with high yields with excellent regioselectivity and stereoselectivity.

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    • Cite

    APA: Copy

    KIAMEHR, MOSTAFA, Mohammadkhani, Leyla, SAFARI, REZA, Jafari, Behzad, & Langer, Peter. (2020). One-Step Synthesis of Novel Heterocycles of Dihydroquinolone-Coumarin in the Presence of ZnBr2 Catalyst. NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), 39(2 (96) ), 171-181. SID. https://sid.ir/paper/410783/en

    Vancouver: Copy

    KIAMEHR MOSTAFA, Mohammadkhani Leyla, SAFARI REZA, Jafari Behzad, Langer Peter. One-Step Synthesis of Novel Heterocycles of Dihydroquinolone-Coumarin in the Presence of ZnBr2 Catalyst. NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN)[Internet]. 2020;39(2 (96) ):171-181. Available from: https://sid.ir/paper/410783/en

    IEEE: Copy

    MOSTAFA KIAMEHR, Leyla Mohammadkhani, REZA SAFARI, Behzad Jafari, and Peter Langer, “One-Step Synthesis of Novel Heterocycles of Dihydroquinolone-Coumarin in the Presence of ZnBr2 Catalyst,” NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), vol. 39, no. 2 (96) , pp. 171–181, 2020, [Online]. Available: https://sid.ir/paper/410783/en

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