GRAPEFRUIT JUICE INTERACTION WITH CYCLOSPORINE IN BONE MARROW TRANSPLANTATION

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GHAVAMZADEH ARDESHIR; RASTEGARPANAH MANSOOR; PAKRAVAN FARIBA

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Journal: Journal of Medical Council of Iran Year:2015 | Volume:33 | Issue:1 Page(s): 35-40

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Title

GRAPEFRUIT JUICE INTERACTION WITH CYCLOSPORINE IN BONE MARROW TRANSPLANTATION

Author(s)

GHAVAMZADEH ARDESHIR | RASTEGARPANAH MANSOOR | PAKRAVAN FARIBA | Issue Writer Certificate

Keywords

CYCLOSPORINEQ3

GRAPEFRUITQ1

BONE MARROW TRANSPLANTATIONQ3

Abstract

Introduction: Recently GRAPEFRUIT juice is known to enhance the bioavailability of several clinically important drugs such as nifedipine, terfenadine, CYCLOSPORINE, ethinylestradiole, midazolam, and triazolam. CYCLOSPORINE is an immunosuppressive agent that used in transplantation for preventation of chronic rejection. GRAPEFRUIT increase in Cmax and AUC of drug mediated by suppression of Cyp3A4 in small intestine wall.Methods: This study has been performed by twenty allogenic bone marrow transplant recipients at shariati hospital in Tehran with (Randomized Cross over Placebo Controlled Study). Subjects were co administrated oral CYCLOSPORINE and GRAPEFRUIT juice as a controlled and water as a placebo, simultaneously and two hours later.Blood samples were collected at 3.5 and 11.5 hours following drug administration. Blood concentration analyzed by specific monoclonal radioimmunoassay (RIA) technique.Results: SPSS version 11 (2002) was used for data analysis. mean and standerd deviation of cyclosponie Cmax was (821±215) ng/ml immediately and 2 hours after using GRAPEFRUIT, which shows %41 higher levels in compersion to drinking water as placebo (578±194) ng/ml (p<0.05), but Cmin blood concentration shows only %21 increase with GRAPEFRUIT versus water as placebo (p>0.05) [319±173 in grapefrait verus 268±140 in water]. The averge systolic and diostolic blood pressare was decreased significantly in GRAPEFRUIT group (p<0.05).Conclusion: This study demonstrated that administration of GRAPEFRUIT juice had increased the CYCLOSPORINE Cmax (%42) at Iranian bone marrow transplant recipients. Because GRAPEFRUIT juice may be a safe and effective instrument to enhance absorption of many therapeutic agents, it is an appropriate means in terms of reducing dosing requirements of many Cyp3A4 substrates such as CYCLOSPORINE.

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APA: Copy

GHAVAMZADEH, ARDESHIR, RASTEGARPANAH, MANSOOR, & PAKRAVAN, FARIBA. (2015). GRAPEFRUIT JUICE INTERACTION WITH CYCLOSPORINE IN BONE MARROW TRANSPLANTATION. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 33(1), 35-40. SID. https://sid.ir/paper/41079/en

Vancouver: Copy

GHAVAMZADEH ARDESHIR, RASTEGARPANAH MANSOOR, PAKRAVAN FARIBA. GRAPEFRUIT JUICE INTERACTION WITH CYCLOSPORINE IN BONE MARROW TRANSPLANTATION. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2015;33(1):35-40. Available from: https://sid.ir/paper/41079/en

IEEE: Copy

ARDESHIR GHAVAMZADEH, MANSOOR RASTEGARPANAH, and FARIBA PAKRAVAN, “GRAPEFRUIT JUICE INTERACTION WITH CYCLOSPORINE IN BONE MARROW TRANSPLANTATION,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 33, no. 1, pp. 35–40, 2015, [Online]. Available: https://sid.ir/paper/41079/en

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