DRUG INDUCED LIVER DISEASES

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EBRAHIMI DARYANI N.; HASHTROUDI A.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Journal of Medical Council of Iran Year:2004 | Volume:22 | Issue:2 Page(s): 129-150

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Information Journal Paper

Title

DRUG INDUCED LIVER DISEASES

Author(s)

EBRAHIMI DARYANI N. | HASHTROUDI A.A. | Issue Writer Certificate

Keywords

HEPATITISQ3

DRUGQ3

LIVER DISEASESQ3

Abstract

Most medications, which are used for the treatment of different diseases are metabolized in the liver. These changes at times produce harmful metabolites that may result in acute or chronic hepatic side effects if not detoxificated by liver enzyme systems. Some DRUGs are directly hepatotoxic. DRUG induced LIVER DISEASES consist of a wide range of hepatic disorders including acute and chronic HEPATITIS, cholestasis, cirrhosis, vascular lesions and even malignancies. This hepatotoxicity is divided into twocategories: Type A, in which predictable side effects related to pharmacologic specifications can occur and type B, with unpredictable, allergic or idiosyncratic presentations. Age, gender, and concomittant preseription DRUGs are important risk factors that are to be taken into consideration while prescribing DRUGs with known hepatotoxic effects. One should keep in mind that DRUG induced liver disease could be possible cause of any hepatic malfunction. The best protocol is to discontinue the DRUG if elevation of liver enzymes or any other liver symptoms appear following consumption of a particular as most DRUG of hepatic side effects are reversible and no sequel remains after discontinuing the DRUG. For some special hepatotoxic DRUGs like Acetaminophen, Isoniazid and Metothrexate, there are special therapeutic and follow up methods which should be known to every physician.

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APA: Copy

EBRAHIMI DARYANI, N., & HASHTROUDI, A.A.. (2004). DRUG INDUCED LIVER DISEASES. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 22(2), 129-150. SID. https://sid.ir/paper/41164/en

Vancouver: Copy

EBRAHIMI DARYANI N., HASHTROUDI A.A.. DRUG INDUCED LIVER DISEASES. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2004;22(2):129-150. Available from: https://sid.ir/paper/41164/en

IEEE: Copy

N. EBRAHIMI DARYANI, and A.A. HASHTROUDI, “DRUG INDUCED LIVER DISEASES,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 22, no. 2, pp. 129–150, 2004, [Online]. Available: https://sid.ir/paper/41164/en

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