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Information Journal Paper

Title

THE EFFECT OF EIGHT-WEEK HIGH INTENSITY INTERVAL TRAINING (HIIT) AND CAFFEINE INTAKE ON THE PGC-1Α EXPRESSION IN SOLEUS MUSCLE IN DIABETIC RATS INDUCED STREPTOZOTOCIN

Pages

  269-280

Keywords

High Intensity Interval Training (HIIT)Q1

Abstract

 Background: The relationship between low PGC-1α expression and several metabolic diseases such as Diabetes and obesity has been identified. This study investigates the effect of eight-week high intensity interval training (HIIT) and Caffeine intake on mitochondrial biogenesis in soleus muscle in diabetic rats induced Streptozotocin. Methods: In a clinical-interventional animal study, 50 male rats were randomly assigned to 5 equal groups (control group(C), Diabetes group(D), Diabetes + Caffeine group(D+Caf), Diabetes + training group(D+T), Diabetes + training + Caffeine group(D+CAF+T)) and subjected to 8 weeks of Caffeine supplementation (70 mg / kg of Caffeine powder was injected five days each week) and 8 weeks of 5 sessions per week with 6 to 12 times, 2-min intervals with intensity of 85-90% of maximal speed. Blood was collected directly from the left ventricle to measure blood glucose levels. The soleus muscle of the left leg was extracted and PGC-1α measured by Western Blot method. Independent t-tests, two-way analysis of variance, and Eta squared (p <0. 05) were used to analyze the data. Results: The results showed that induction of Diabetes significantly increased blood glucose (P <0. 01) and significantly decreased mRNAPGC-1α (P = 0. 002). Also, both high-intensity interval training (p = 0. 001) and Caffeine supplementation (p = 0. 03) significantly increased mRNAPGC-1α . Conclusion: Based on the results of this study, it is possible to suggest the use of HIIT and Caffeine consumption as an effective intervention in increasing mitochondrial biogenesis in diabetics. However, a clear statement in this regard requires further research in this area.

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    APA: Copy

    KHALILI, MORTEZA, Sadeghi, Abbas, & Maleki, Mohammad Javad. (2020). THE EFFECT OF EIGHT-WEEK HIGH INTENSITY INTERVAL TRAINING (HIIT) AND CAFFEINE INTAKE ON THE PGC-1Α EXPRESSION IN SOLEUS MUSCLE IN DIABETIC RATS INDUCED STREPTOZOTOCIN. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 19(5 ), 269-280. SID. https://sid.ir/paper/412576/en

    Vancouver: Copy

    KHALILI MORTEZA, Sadeghi Abbas, Maleki Mohammad Javad. THE EFFECT OF EIGHT-WEEK HIGH INTENSITY INTERVAL TRAINING (HIIT) AND CAFFEINE INTAKE ON THE PGC-1Α EXPRESSION IN SOLEUS MUSCLE IN DIABETIC RATS INDUCED STREPTOZOTOCIN. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2020;19(5 ):269-280. Available from: https://sid.ir/paper/412576/en

    IEEE: Copy

    MORTEZA KHALILI, Abbas Sadeghi, and Mohammad Javad Maleki, “THE EFFECT OF EIGHT-WEEK HIGH INTENSITY INTERVAL TRAINING (HIIT) AND CAFFEINE INTAKE ON THE PGC-1Α EXPRESSION IN SOLEUS MUSCLE IN DIABETIC RATS INDUCED STREPTOZOTOCIN,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 19, no. 5 , pp. 269–280, 2020, [Online]. Available: https://sid.ir/paper/412576/en

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