Effect of aqueous and alcoholic extracts of Ziziphora clinopodioides on apoptosis and alteration of caspase-3 and caspase-9 gene expression in anterior horn neurons of the spinal cord after sciatic nerve compression in male rats

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Abdolamir Abdolsamad Halaf Iman; TEHRANIPOUR MARYAM; Mahmodzadeh Akharat Homa

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Birjand University of Medical Sciences Year:2021 | Volume:28 | Issue:3 Page(s): 222-235

Download Full-Text

Persian Verion

View:

208

Download:

Cites:

Information Journal Paper

Title

Effect of aqueous and alcoholic extracts of Ziziphora clinopodioides on apoptosis and alteration of caspase-3 and caspase-9 gene expression in anterior horn neurons of the spinal cord after sciatic nerve compression in male rats

Author(s)

Abdolamir Abdolsamad Halaf Iman | TEHRANIPOUR MARYAM | Mahmodzadeh Akharat Homa | Issue Writer Certificate

Keywords

ApoptosisQ2

DegenerationQ2

NeuronQ2

Ziziphora clinopodioidesQ1

Abstract

Background and Aim: Caspase family genes promote Degeneration and are involved in apoptotic processes. The Ziziphora clinopodioides from the mint family (Lamiaceae) is one of the plants strong with antiinflammatory effects and involved in the process of nervous system repair. The present study aimed to determine the effects of aqueous and alcoholic extracts of Ziziphora clinopodioides on Apoptosis and alteration of caspase-3 and caspase-9 gene expression after sciatic nerve compression in male rats. Materials and Methods: In the present study, 24 male Wistar rats weighing 200-250 g were randomly assigned to four groups (n=6 in each group): control, compression, treatment with aqueous, and treatment with alcoholic extracts at a dose of 75 mg/kg. The extract was injected intraperitoneally on compression day and seven days later. After 28 days, samples were taken from the lumbar spinal cord subsequent to performing the perfusion method, and the samples were studied in two ways. Thereafter, in each group, total RNA was extracted from the lumbar spinal cord, cDNA was synthesized; subsequently, the expression changes in caspases-3 and caspases-9 were compared. Results: Based on the results, the number of Neurons significantly decreased in the compression group, as compared to that in the control group, and demonstrated a significant increase in the aqueous extract group, in comparison with the compression group. Furthermore, the amount of caspases-3 and caspases-9 expression increased significantly in the compression group, compared to that in the control group. Moreover, caspase-3 and caspase-9 gene expression increased in the aqueous extract group, as compared to that in the compression group (P<0. 001). Conclusion: It seems that, the extract of Ziziphora clinopodioides has neuroprotective effects due to its antioxidant and anti-inflammatory properties, as well as phenolic and flavonoid compounds, such as pulegone.

Cites

No record.

References

No record.

Cite

APA: Copy

Abdolamir Abdolsamad Halaf, Iman, TEHRANIPOUR, MARYAM, & Mahmodzadeh Akharat, Homa. (2021). Effect of aqueous and alcoholic extracts of Ziziphora clinopodioides on apoptosis and alteration of caspase-3 and caspase-9 gene expression in anterior horn neurons of the spinal cord after sciatic nerve compression in male rats. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 28(3 ), 222-235. SID. https://sid.ir/paper/413522/en

Vancouver: Copy

Abdolamir Abdolsamad Halaf Iman, TEHRANIPOUR MARYAM, Mahmodzadeh Akharat Homa. Effect of aqueous and alcoholic extracts of Ziziphora clinopodioides on apoptosis and alteration of caspase-3 and caspase-9 gene expression in anterior horn neurons of the spinal cord after sciatic nerve compression in male rats. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2021;28(3 ):222-235. Available from: https://sid.ir/paper/413522/en

IEEE: Copy

Iman Abdolamir Abdolsamad Halaf, MARYAM TEHRANIPOUR, and Homa Mahmodzadeh Akharat, “Effect of aqueous and alcoholic extracts of Ziziphora clinopodioides on apoptosis and alteration of caspase-3 and caspase-9 gene expression in anterior horn neurons of the spinal cord after sciatic nerve compression in male rats,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 3 , pp. 222–235, 2021, [Online]. Available: https://sid.ir/paper/413522/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops