Molecular mechanism of reduction in aflatoxin B1 biosynthesis by Heracleum persicum and Peganum harmala extracts as indicated by traditional medical knowledge of Iran

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Safari Nassim; Hemmati Roghayeh; Mirabzadeh Ardakani Mehran; EINI OMID

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Journal: JOURNAL OF ISLAMIC AND IRANIAN TRADITIONAL MEDICINE Year:2021 | Volume:12 | Issue:1 Page(s): 1-14

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Title

Molecular mechanism of reduction in aflatoxin B1 biosynthesis by Heracleum persicum and Peganum harmala extracts as indicated by traditional medical knowledge of Iran

Author(s)

Safari Nassim | Hemmati Roghayeh | Mirabzadeh Ardakani Mehran | EINI OMID | Issue Writer Certificate

Keywords

Aflatoxin B1Q1

AspergillusQ1

Gene ExpressionQ1

Heracleum persicumQ1

Peganum harmalaQ1

Abstract

Background and Purpose: Aflatoxin B1 (AFB1), produced by several species of Aspergillus on a wide range of food products, is a serious agricultural and medical threat. It is classified as a class one carcinogen, due to carcinogenic, mutagenic, teratogenic, hepatotoxic and immunosuppressive effects. Use of natural compounds that are able to prevent aflatoxin production, can be an alternative strategy to limit food and feed contamination in line with sustainable agriculture. Materials and Methods: Based on Persian traditional medicine resources, this study evaluated the inhibitory effect of Heracleum persicum and Peganum harmala extracts on fungal growth and Aflatoxin B1 production. In addition, we used LC-MS analysis and analyzed some key genes that are involved in the AFB1-producing gene cluster (aflM, aflP and aflR), to investigate the inhibition mechanisms of fungal growth and AFB1 by the herbal extracts, at the molecular and transcriptional level. Results: In this study we showed that the extracts of H. persicum and P. harmala at concentrations of 4 and 6 mg/mL exhibited a 100% inhibitory effect on Aflatoxin B1 production despite incomplete inhibition of fungal growth. The results of this study showed that addition of 4 mg/mL of Heracleum persicum extract in the YES culture medium of A. flavus leads to almost complete inhibition of aflM, aflP Gene Expression. Conclusion: To summarize, the decrease in aflatoxin biosynthesis by H. persicum and P. harmala extracts can be due to decreased expression level of the associated gene cluster. Among the investigated genes, we found that the aflP gene is likely more involved in aflatoxin inhibition and probably plays a more critical role. Overall, this study reveals the anti-aflatoxigenic mechanisms of the selected plant extracts at the Gene Expression level and provides evidence for their use in food, feed and medicinal plants that are prone to this contamination.

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APA: Copy

Safari, Nassim, Hemmati, Roghayeh, Mirabzadeh Ardakani, Mehran, & EINI, OMID. (2021). Molecular mechanism of reduction in aflatoxin B1 biosynthesis by Heracleum persicum and Peganum harmala extracts as indicated by traditional medical knowledge of Iran. JOURNAL OF ISLAMIC AND IRANIAN TRADITIONAL MEDICINE, 12(1 ), 1-14. SID. https://sid.ir/paper/413585/en

Vancouver: Copy

Safari Nassim, Hemmati Roghayeh, Mirabzadeh Ardakani Mehran, EINI OMID. Molecular mechanism of reduction in aflatoxin B1 biosynthesis by Heracleum persicum and Peganum harmala extracts as indicated by traditional medical knowledge of Iran. JOURNAL OF ISLAMIC AND IRANIAN TRADITIONAL MEDICINE[Internet]. 2021;12(1 ):1-14. Available from: https://sid.ir/paper/413585/en

IEEE: Copy

Nassim Safari, Roghayeh Hemmati, Mehran Mirabzadeh Ardakani, and OMID EINI, “Molecular mechanism of reduction in aflatoxin B1 biosynthesis by Heracleum persicum and Peganum harmala extracts as indicated by traditional medical knowledge of Iran,” JOURNAL OF ISLAMIC AND IRANIAN TRADITIONAL MEDICINE, vol. 12, no. 1 , pp. 1–14, 2021, [Online]. Available: https://sid.ir/paper/413585/en

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