SYNERGISTIC EFFECT OF HIGH INTENSITY INTERVAL TRAINING (HIIT) COMBINED WITH CURCUMIN ON BAX AND BCL-2 GENE EXPRESSION IN SOLEUS MUSCLE OF DIABETIC RATS

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DELFAN MARYAM; Rabiee Malihe; Amadeh Juybari Raheleh

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Journal: Iranian Journal of Diabetes and Metabolism Year:2021 | Volume:20 | Issue:3 Page(s): 210-219

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Title

SYNERGISTIC EFFECT OF HIGH INTENSITY INTERVAL TRAINING (HIIT) COMBINED WITH CURCUMIN ON BAX AND BCL-2 GENE EXPRESSION IN SOLEUS MUSCLE OF DIABETIC RATS

Author(s)

DELFAN MARYAM | Rabiee Malihe | Amadeh Juybari Raheleh | Issue Writer Certificate

Keywords

DiabetesQ2

InsulinQ3

High Intensity Interval TrainingQ1

CurcuminQ2

ApoptosisQ2

Abstract

Background: Imbalance of apoptotic factors plays important role in pathogenesis of Diabetes. Considering the role of Curcumin supplementation and high-intensity interval training (HIIT) on these factors, the aim of this study was to investigate effects of four weeks of HIIT with Curcumin supplementation on Bax and Bcl-2 gene expression in the soleus muscle of diabetic rats. Methods: Present study was experimental research. 30 male Wistar rats were divided into one normal control (NC), and four diabetic groups: control (DC), supplement (SDC), high-intensity interval training (DHIIT) and high-intensity interval training supplement (SDHIIT). The training protocol was performed five days a week for four weeks, which included five to seven two-minute intervals at 80 to 90% of maximum power until exhaustion and one-minute recovery at 30% of maximum power until exhaustion. At the same time, Curcumin gavage at a dose of 100 mg/kg was performed daily. Bax and BCL-2 gene expression levels were measured by the qReal-TimePCR method and data were analyzed by two-way analysis of variance at a significant level of p≥ 0. 05. Results: Bcl-2 gene expression was significantly increased in DHIIT and SDHIIT groups compared to DC (P= 0. 000). Also, a significant decrease in Bax gene expression was observed in DHIIT and SDHIIT groups compared to DC (P=0. 000). There was a significant difference between DHIIT and SDHIIT in Bcl-2 (P=0. 000) and Bax (P=0. 013) gene expression. Conclusion: It seems that HIIT in combination with Curcumin supplementation, is more effective in improving the balance between Apoptosis factors than any of these interventions alone.

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APA: Copy

DELFAN, MARYAM, Rabiee, Malihe, & Amadeh Juybari, Raheleh. (2021). SYNERGISTIC EFFECT OF HIGH INTENSITY INTERVAL TRAINING (HIIT) COMBINED WITH CURCUMIN ON BAX AND BCL-2 GENE EXPRESSION IN SOLEUS MUSCLE OF DIABETIC RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 20(3 ), 210-219. SID. https://sid.ir/paper/413865/en

Vancouver: Copy

DELFAN MARYAM, Rabiee Malihe, Amadeh Juybari Raheleh. SYNERGISTIC EFFECT OF HIGH INTENSITY INTERVAL TRAINING (HIIT) COMBINED WITH CURCUMIN ON BAX AND BCL-2 GENE EXPRESSION IN SOLEUS MUSCLE OF DIABETIC RATS. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2021;20(3 ):210-219. Available from: https://sid.ir/paper/413865/en

IEEE: Copy

MARYAM DELFAN, Malihe Rabiee, and Raheleh Amadeh Juybari, “SYNERGISTIC EFFECT OF HIGH INTENSITY INTERVAL TRAINING (HIIT) COMBINED WITH CURCUMIN ON BAX AND BCL-2 GENE EXPRESSION IN SOLEUS MUSCLE OF DIABETIC RATS,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 20, no. 3 , pp. 210–219, 2021, [Online]. Available: https://sid.ir/paper/413865/en

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