TREATMENTOF REFRACTORY CONVULSIVE STATUS EPILEPTICUS WITH CONTINUOUS MIDAZOLAM
INFUSION

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GHOFRANI M.; BARZEGAR M.

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Journal: Journal of Medical Council of Iran Year:2000 | Volume:18 | Issue:2 Page(s): 94-99

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Title

TREATMENTOF REFRACTORY CONVULSIVE STATUS EPILEPTICUS WITH CONTINUOUS MIDAZOLAM INFUSION

Author(s)

GHOFRANI M. | BARZEGAR M. | Issue Writer Certificate

Keywords

STATUS EPILEPTICUSQ4

REFRACTORY SEIZUREQ3

MIDAZOLAMQ3

Abstract

Continuous MIDAZOLAM infusion was tried as treatment for 15 children with refractory convulsive STATUS EPILEPTICUS, at the mofid children hospital over one year period. Ten patients had generalized convulsive STATUS EPILEPTICUS and 5 had partial one. All patients had received intravenous diazepam, phenobarbital and phenytion, before MIDAZOLAM infusion was started (0.15µg/kg bolus, followed by 1-6 µg/kg/min infusion). The siezures were controled in 9 out of 10 (%90) patients with generalized status, and 2 of 5 (40%) cases of partial status. The average required necessary period for complete cessation of seizures in generalized status was about one hour. The mean infusion rate was 3.6µg/kg/min. In two of children with generalized status, decreased oxygen saturation necessitated endotracheal intubation and mechanical ventilation. This modality of therapy did not cause any metabolic derangement in any of our cases. Thus MIDAZOLAM infusion is an effective and safe therapeutic approach for management of childhood refractory generalized convulsive STATUS EPILEPTICUS, although its effect in controlling partial type of convulsive STATUS EPILEPTICUS is not remarkable in comparison to the generalized one.

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APA: Copy

GHOFRANI, M., & BARZEGAR, M.. (2000). TREATMENTOF REFRACTORY CONVULSIVE STATUS EPILEPTICUS WITH CONTINUOUS MIDAZOLAM INFUSION. JOURNAL OF MEDICAL COUNCIL OF I.R.I., 18(2), 94-99. SID. https://sid.ir/paper/41428/en

Vancouver: Copy

GHOFRANI M., BARZEGAR M.. TREATMENTOF REFRACTORY CONVULSIVE STATUS EPILEPTICUS WITH CONTINUOUS MIDAZOLAM INFUSION. JOURNAL OF MEDICAL COUNCIL OF I.R.I.[Internet]. 2000;18(2):94-99. Available from: https://sid.ir/paper/41428/en

IEEE: Copy

M. GHOFRANI, and M. BARZEGAR, “TREATMENTOF REFRACTORY CONVULSIVE STATUS EPILEPTICUS WITH CONTINUOUS MIDAZOLAM INFUSION,” JOURNAL OF MEDICAL COUNCIL OF I.R.I., vol. 18, no. 2, pp. 94–99, 2000, [Online]. Available: https://sid.ir/paper/41428/en

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