The Response of Mir133a and Some Markers of Cardiac Hypertrophy to Endurance Training

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Shahin Jahromi Susan; ABBASSI DALOII ASIEH; BARARI ALIREZA; Saeidi Ayoub

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Journal: Pars Journal of Medical Sciences Year:2020 | Volume:18 | Issue:1 Page(s): 50-57

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Information Journal Paper

Title

The Response of Mir133a and Some Markers of Cardiac Hypertrophy to Endurance Training

Author(s)

Shahin Jahromi Susan | ABBASSI DALOII ASIEH | BARARI ALIREZA | Saeidi Ayoub | Issue Writer Certificate

Keywords

ExerciseQ1

Cardiac HypertrophyQ1

miR-133aQ1

IGF-1Q1

IGF-RQ1

Abstract

Introduction: The effect of Exercise on the expression of genes affecting Cardiac Hypertrophy is unclear. Evidence suggests that some miRNAs play an important role in improving heart function. The aim of this study was to evaluate the response of miR-133a and some markers of Cardiac Hypertrophy to endurance training. Methods and Materials: To implementation of this experimental research, 10 male Wistar Rats (4-6 weeks old) randomly were divided into 2 groups control and endurance training. Endurance training performed 5 days a week at a speed of 25 m/min and a gradient of zero degrees for 12 weeks. The expression of miR-133a, IGF-1 and IGF-R genes were measured by Real Time PCR. Data were analyzed by independent t-test at the P<0. 05. Results: The results showed that after 12 weeks of aerobic Exercise the expression of miR-133a and IGF-1 gene was significantly higher in the Exercise group than in the control group (P=0. 001). Also, after 12 weeks of aerobic training, no significant difference was observed in IGF-R gene expression between the two groups (P <0. 05). Conclusion: According to the findings of the present study, twelve weeks of aerobic Exercise may possibly increase cardiac protection activities through Cardiac Hypertrophy indices.

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APA: Copy

Shahin Jahromi, Susan, ABBASSI DALOII, ASIEH, BARARI, ALIREZA, & Saeidi, Ayoub. (2020). The Response of Mir133a and Some Markers of Cardiac Hypertrophy to Endurance Training. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 18(1 ), 50-57. SID. https://sid.ir/paper/414449/en

Vancouver: Copy

Shahin Jahromi Susan, ABBASSI DALOII ASIEH, BARARI ALIREZA, Saeidi Ayoub. The Response of Mir133a and Some Markers of Cardiac Hypertrophy to Endurance Training. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2020;18(1 ):50-57. Available from: https://sid.ir/paper/414449/en

IEEE: Copy

Susan Shahin Jahromi, ASIEH ABBASSI DALOII, ALIREZA BARARI, and Ayoub Saeidi, “The Response of Mir133a and Some Markers of Cardiac Hypertrophy to Endurance Training,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 18, no. 1 , pp. 50–57, 2020, [Online]. Available: https://sid.ir/paper/414449/en

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