مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

292
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

0
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Protective Effect of Hydroalcoholic Extract of Carob (Ceratonia Siliqua) on Testicular Tissue in Adult Rats Treated with Doxorubicin

Pages

  380-394

Keywords

Carob (Ceratonia Siliqua)Q1
RatQ2

Abstract

 Background: Doxorubicin is one of the most commonly used anticancer drugs. The purpose of this study was to investigate the protective effect of hydroalcoholic extract of Carob (CeRatonia Siliqua) on testicular tissue in adult Rats treated with Doxorubicin. Materials and Methods: In this experimental study, 56 adult male Wistar Rats were used in 8 groups of seven. The control group received only ordinary water and food. The sham group received distilled water at a dose of 3 mg / kg by intraperitoneal injection. The sham group 1 received dose of Doxorubicin (3mg / kg) once weekly for 4 weeks intraperitoneally. The sham group 2 group received (600 mg / kg) maximum dose of hydroalcoholic extract of Carob (CeRatonia Siliqua) for 48 days by gavage method. Experimental groups 1, 2 and 3 received Doxorubicin with 3 mg/kg once weekly for 4 weeks intraperitoneally and 150, 300 and 600 mg / kg of hydroalcoholic extract of Carob (CeRatonia Siliqua) for 48 days with gavage method. Hematoxylin-eosin staining method was used to test the testicular tissue. Results: The mean body weight, number of spermatogonial cells, spermatocyte count, spermatocyte count and number of leydig cells in the experimental group receiving Doxorubicin and 300 mg / kg dose of hydroalcoholic extract of Carob (CeRatonia Siliqua) increased significantly compared to the group receiving Doxorubicin. In experimental groups receiving Doxorubicin and 150 and 600 mg / kg doses of hydroalcoholic extracts of Carob (CeRatonia Siliqua), the mean number of spermatogonia, spermatocyte, spermatid and leydig cells decreased significantly compared to control and sham groups (P <0. 05). Histologic studies also showed that the amount of shrinkage in testicular tissue in the experimental group receiving Doxorubicin and 300 mg / kg dose of hydroalcoholic extract of Carob (CeRatonia Siliqua), as compared with the group receiving Doxorubicin, was decreased, which indicates the effect of this dose on the recovery of testicular tissue. Conclusion: Hydroalcoholic extract of 300 mg / kg dose of Carob (CeRatonia Siliqua) has a protective effect on spermatogenesis poisoning induced by Doxorubicin.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Mehdi Khani, Hengameh, SHARIATI, MEHRDAD, FOROZANFAR, MOHSEN, & HOSSEINI, SEYED EBRAHIM. (2020). Protective Effect of Hydroalcoholic Extract of Carob (Ceratonia Siliqua) on Testicular Tissue in Adult Rats Treated with Doxorubicin. ALBORZ UNIVERSITY MEDICAL JOURNAL, 9(4 ), 380-394. SID. https://sid.ir/paper/414798/en

    Vancouver: Copy

    Mehdi Khani Hengameh, SHARIATI MEHRDAD, FOROZANFAR MOHSEN, HOSSEINI SEYED EBRAHIM. Protective Effect of Hydroalcoholic Extract of Carob (Ceratonia Siliqua) on Testicular Tissue in Adult Rats Treated with Doxorubicin. ALBORZ UNIVERSITY MEDICAL JOURNAL[Internet]. 2020;9(4 ):380-394. Available from: https://sid.ir/paper/414798/en

    IEEE: Copy

    Hengameh Mehdi Khani, MEHRDAD SHARIATI, MOHSEN FOROZANFAR, and SEYED EBRAHIM HOSSEINI, “Protective Effect of Hydroalcoholic Extract of Carob (Ceratonia Siliqua) on Testicular Tissue in Adult Rats Treated with Doxorubicin,” ALBORZ UNIVERSITY MEDICAL JOURNAL, vol. 9, no. 4 , pp. 380–394, 2020, [Online]. Available: https://sid.ir/paper/414798/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top