Evaluation of Cell Biomarker Gene Expression (CD34) in ALL Patients and Healthy Controls Expression (CD34) in People with Leukemia

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Moradizadeh g.; ZIA JAHROMI N.; SAZGARA H.

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Journal Paper

Paper Information

Journal: JOURNAL OF ADVANCED BIOMEDICAL SCIENCES Year:2020 | Volume:10 | Issue:3 Page(s): 2578-2587

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Information Journal Paper

Title

Evaluation of Cell Biomarker Gene Expression (CD34) in ALL Patients and Healthy Controls Expression (CD34) in People with Leukemia

Author(s)

Moradizadeh g. | ZIA JAHROMI N. | SAZGARA H. | Issue Writer Certificate

Keywords

CD34Q2

Real-time RT PCRQ1

leukemiaQ1

cancer stem cellsQ2

Abstract

Background & Objective: CD34 is a prognostic factor in determining the prognosis of patients with acute myeloid leukemia. Since the relationship between expression of the marker of the CD34 cell line and many cancers has been proven today, in this study, the measurement of the expression of this marker with leukemia was investigated. Materials & Methods: The present study is a case-control study performed on 30 healthy blood samples and 30 blood samples from blood donors. Lymphocytes were isolated using Ficole method. RNA was extracted. After synthesis of cDNA, expression regions were determined using Real Time RT-PCR with an internal control of GAPDH. Results: After performing the PCR reaction with specific primers in Real Time RT PCR and analyzing the results, the expression of CD34 gene in the blood of cancer patients was increased compared to healthy subjects (F = 21. 588, P-Val = 0. 002). Conclusion: Finding new biomarkers, which are a common indicator of cancer, can help with early diagnosis and recovery during cancerous illnesses. By reviewing these biomarkers, it is possible to develop new anti-cancer drugs that can target cancerous cells and prevent growth from growing into cancerous cells.

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APA: Copy

Moradizadeh, g., ZIA JAHROMI, N., & SAZGARA, H.. (2020). Evaluation of Cell Biomarker Gene Expression (CD34) in ALL Patients and Healthy Controls Expression (CD34) in People with Leukemia. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, 10(3 ), 2578-2587. SID. https://sid.ir/paper/415194/en

Vancouver: Copy

Moradizadeh g., ZIA JAHROMI N., SAZGARA H.. Evaluation of Cell Biomarker Gene Expression (CD34) in ALL Patients and Healthy Controls Expression (CD34) in People with Leukemia. JOURNAL OF ADVANCED BIOMEDICAL SCIENCES[Internet]. 2020;10(3 ):2578-2587. Available from: https://sid.ir/paper/415194/en

IEEE: Copy

g. Moradizadeh, N. ZIA JAHROMI, and H. SAZGARA, “Evaluation of Cell Biomarker Gene Expression (CD34) in ALL Patients and Healthy Controls Expression (CD34) in People with Leukemia,” JOURNAL OF ADVANCED BIOMEDICAL SCIENCES, vol. 10, no. 3 , pp. 2578–2587, 2020, [Online]. Available: https://sid.ir/paper/415194/en

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