ASSOCIATION OF HYPERINSULINEMIA AND FASTING PLASMA INSULIN WITH CORONARY ARTERY DISEASE IN NONDIABETIC IRANIAN SUBJECTS

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RAEISZADEH F.; RAHMANI M.; KOHKAN A.; AZIZI F.; SHIRAZI GH.R.; MOTAMEDI M.R.

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Journal: Research in Medicine Year:2002 | Volume:25 | Issue:4 Page(s): 219-229

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Title

ASSOCIATION OF HYPERINSULINEMIA AND FASTING PLASMA INSULIN WITH CORONARY ARTERY DISEASE IN NONDIABETIC IRANIAN SUBJECTS

Author(s)

Keywords

INSULINQ2

APOLIPOPROTEINQ4

CORONARY ARTERY DISEASEQ3

Abstract

Materials and methods: l78 CAD+ (139 men and 39 women) and 86 CAD- (66 men and 20 women) subjects aged 31-72 years had entered this case-control study. They underwent their first coronary angiography and had a fasting blood sugar<126 mg/dl with a negative history of diabetus mellitus or hypoglycemic drug usage. Fasting plasma INSULIN was determined via immunoradiometric assay (IRMA) and plasma APOLIPOPROTEINs were measured through immunoturbidometric assay. Results: CAD+ patients were older than nondiabetic CAD- subjects (55.5±8 vs. 52±9 years, p<0.001). CAD+ patients had higher total cholesterol (199±41 vs. 19H45 mg/dl, p<0.01) and LDL level (124±40 vs. 113±41 mg/dl, p<0.05), and lower HDL level (46±12 vs. 51± 13mg/dl, p<0.01) when comparing with CAD- subjects. There was no significant difference in fasting plasma INSULIN(13±7 vs. 12±7 µIu/ml) and APOLIPOPROTEIN A-I( 161±16 vs. 164±21 mg/dl) between cases and controls, whereas CAD+ patients had significantly higher APOLIPOPROTEIN B level (93±21 vs. 85±18 mg/dl, p<0.01). Multiple logistic regression analysis had revealed that APOLIPOPROTEIN B is the only discriminator of CAD. Conclusion: Our findings suggest APOLIPOPROTEIN B level is a useful indicator of CAD, meanwhile plasma INSULIN level is not a risk factor for CORONARY ARTERY DISEASE in nondiabetic Iranian subjects.

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APA: Copy

RAEISZADEH, F., RAHMANI, M., KOHKAN, A., AZIZI, F., SHIRAZI, GH.R., & MOTAMEDI, M.R.. (2002). ASSOCIATION OF HYPERINSULINEMIA AND FASTING PLASMA INSULIN WITH CORONARY ARTERY DISEASE IN NONDIABETIC IRANIAN SUBJECTS. PAJOUHESH DAR PEZESHKI, 25(4), 219-229. SID. https://sid.ir/paper/41579/en

Vancouver: Copy

RAEISZADEH F., RAHMANI M., KOHKAN A., AZIZI F., SHIRAZI GH.R., MOTAMEDI M.R.. ASSOCIATION OF HYPERINSULINEMIA AND FASTING PLASMA INSULIN WITH CORONARY ARTERY DISEASE IN NONDIABETIC IRANIAN SUBJECTS. PAJOUHESH DAR PEZESHKI[Internet]. 2002;25(4):219-229. Available from: https://sid.ir/paper/41579/en

IEEE: Copy

F. RAEISZADEH, M. RAHMANI, A. KOHKAN, F. AZIZI, GH.R. SHIRAZI, and M.R. MOTAMEDI, “ASSOCIATION OF HYPERINSULINEMIA AND FASTING PLASMA INSULIN WITH CORONARY ARTERY DISEASE IN NONDIABETIC IRANIAN SUBJECTS,” PAJOUHESH DAR PEZESHKI, vol. 25, no. 4, pp. 219–229, 2002, [Online]. Available: https://sid.ir/paper/41579/en

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