Investigation of nanoniosomal formulation containing doxorubicin effect on ovarian cancer cell line (OVCAR-3 cell line)

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Ghashghaei Mariya; Akhlaghi Milad; Akbarzadeh Khyavi Azim; HAGHIROSADAT BIBI FATEMEH

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2021 | Volume:11 | Issue:43 Page(s): 47-61

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Information Journal Paper

Title

Investigation of nanoniosomal formulation containing doxorubicin effect on ovarian cancer cell line (OVCAR-3 cell line)

Author(s)

Ghashghaei Mariya | Akhlaghi Milad | Akbarzadeh Khyavi Azim | HAGHIROSADAT BIBI FATEMEH | Issue Writer Certificate

Keywords

Ovarian CancerQ1

NanomedicineQ1

DoxorubicinQ1

Iau ScienceQ1

Abstract

Aim and Background: Cancer is a major cause of mortality in the world. Treatment of Cancer through drug therapy/chemotherapy faces the challenges of drug delivery. Drug delivery systems such as niosomes provided high efficiency and targeted treatment. The aim of this study was to prepare a new formula of niosomal nano system containing doxorubicin as the cancer therapy drug. Changing the tissue distribution of drug leads to drug effect improvement and reducing its cytotoxicity. Materials and Methods: Doxorubicin encapsulated niosomes were synthesized using thin-film method. A certain amount of Span-60 and Cholesterol dissolved by chloroform in a round bottom balloon. Rotary evaporator was used in order to remove the organic solvent and form the thin-film. The thin-film was hydrated by doxorubicin and PBS solution using rotary evaporator in 10° C higher than span-60 transition phase. Entrapment Efficiency and release profile were investigated using dialysis and spectrophotometry. Size reduction was applied by probe sonicating. Nanoparticles average diameter and zeta potentiol was measured using DLS technique and Zeta sizer. The optimum formula was PEGylated and its cytotoxicity investigated through MTT assay on Ovarian cancer cell line and fibroblast normal cells. Results: The diameter of optimized and PEGylated niosomal formulation was 172. 5 nm and entrapment efficiency of PEGylated doxorubicin system was about 95. 83± 1. 18. release studies result in PBS buffer at 37° C was the sign of PEGylated nanoniosomes efficiency in controlling the drug release, which the release percent of drug after 48 hours was 20. 52 and its cytotoxicity was higher than the free drug. Conclusion: The study demonstrates using of drug delivery carriers such as synthesized nanoniosomes has an effective role in increasing the efficacy and reducing the consumed dosages of drug.

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Immunological Evaluation of Nisome Nanostructure Containing Three-Component Chimeric Immunogen of Target Antigens as a Candidate for Brucellosis Vaccine

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APA: Copy

Ghashghaei, Mariya, Akhlaghi, Milad, Akbarzadeh Khyavi, Azim, & HAGHIROSADAT, BIBI FATEMEH. (2021). Investigation of nanoniosomal formulation containing doxorubicin effect on ovarian cancer cell line (OVCAR-3 cell line). NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 11(43 ), 47-61. SID. https://sid.ir/paper/416309/en

Vancouver: Copy

Ghashghaei Mariya, Akhlaghi Milad, Akbarzadeh Khyavi Azim, HAGHIROSADAT BIBI FATEMEH. Investigation of nanoniosomal formulation containing doxorubicin effect on ovarian cancer cell line (OVCAR-3 cell line). NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2021;11(43 ):47-61. Available from: https://sid.ir/paper/416309/en

IEEE: Copy

Mariya Ghashghaei, Milad Akhlaghi, Azim Akbarzadeh Khyavi, and BIBI FATEMEH HAGHIROSADAT, “Investigation of nanoniosomal formulation containing doxorubicin effect on ovarian cancer cell line (OVCAR-3 cell line),” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 11, no. 43 , pp. 47–61, 2021, [Online]. Available: https://sid.ir/paper/416309/en

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