GLUTATHION-S-TRANSFERASE MI, TI AND PI GENE POLYMORPHISMS IN AUTOIMMUNE HEPATITIS

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ALIDOUST L.; ZAFARGHANDI M.; AGAH M.R.; SANDI H.; ZALI MOHAMMAD REZA

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Journal: Research in Medicine Year:2006 | Volume:30 | Issue:2 Page(s): 161-167

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Title

GLUTATHION-S-TRANSFERASE MI, TI AND PI GENE POLYMORPHISMS IN AUTOIMMUNE HEPATITIS

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Keywords

GLUTATHIONE S-TRANSFERASEQ3

GSTM1Q2

GSTT1Q2

GSTP1Q2

AUTOIMMUNE HEPATITISQ4

Abstract

Background: AUTOIMMUNE HEPATITIS (AIH) is a chronic inflammatory liver disorder of unknown etiology. The search for gene polymorphisms has suggested that Glutathion-s-transferase (GST), enzymes that metabolize carcinogens, drug, and foreign compounds, may play a role in susceptibility to autoimmune liver disease and its severity. The objective of this study was to investigate for a relationship between the glutathion-s-transferase M1, T1 and PI genotypes and type 1 AUTOIMMUNE HEPATITIS.Materials and methods: In a case-control study, we investigated glutathion S-transferase (GST) PI He (105) Val, T1, and M1 polymorphisms in 64 type 1 AIH patients and 100 healthy controls that were selected consecutively. GSTM1 and GSTT1 polymorphisms were analyzed by a Multiplex PCR procedure, whereas GSTPI polymorphism was analyzed by PCR-RFLP.Results: GSTM1 and GSTT1 null genotypes (deletions) were determined in 33(51.6%) and 15 (23.4%) patients with type 1 AIH, and 56 (56%) and 22(22%) controls, respectively. Comparison of patients and controls relative to GSTM1 and GSTT1 genotypes revealed no significant difference between them. Regarding GSTP1 genotypes, 25(39.1%) heterozygotes, 7 (10.9%) homozygotes in the case group and 38(38%) heterozygotes, 14(14%) homozygotes in the control group were observed. The allele frequency of GSTP1 (Val) was 30.4% and 33 % in patients and controls, respectively. There were no significant variation in GSTP1 frequencies between cases and controls.Conclusion: These results suggest that there is no association between GST M1, GSTT1 and GSTP1 gene polymorphisms and type 1 AUTOIMMUNE HEPATITIS in Iran.

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APA: Copy

ALIDOUST, L., ZAFARGHANDI, M., AGAH, M.R., SANDI, H., & ZALI, MOHAMMAD REZA. (2006). GLUTATHION-S-TRANSFERASE MI, TI AND PI GENE POLYMORPHISMS IN AUTOIMMUNE HEPATITIS. PAJOUHESH DAR PEZESHKI, 30(2), 161-167. SID. https://sid.ir/paper/41701/en

Vancouver: Copy

ALIDOUST L., ZAFARGHANDI M., AGAH M.R., SANDI H., ZALI MOHAMMAD REZA. GLUTATHION-S-TRANSFERASE MI, TI AND PI GENE POLYMORPHISMS IN AUTOIMMUNE HEPATITIS. PAJOUHESH DAR PEZESHKI[Internet]. 2006;30(2):161-167. Available from: https://sid.ir/paper/41701/en

IEEE: Copy

L. ALIDOUST, M. ZAFARGHANDI, M.R. AGAH, H. SANDI, and MOHAMMAD REZA ZALI, “GLUTATHION-S-TRANSFERASE MI, TI AND PI GENE POLYMORPHISMS IN AUTOIMMUNE HEPATITIS,” PAJOUHESH DAR PEZESHKI, vol. 30, no. 2, pp. 161–167, 2006, [Online]. Available: https://sid.ir/paper/41701/en

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