SERUM IRON, HEPATIC IRON DEPOSITION, AND INFLAMMATORY HEPATIC NECROSIS/FIBROSIS IN CHRONIC HEPATITIS C

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MOHAMMADALIZADEH A.H.; FALAHIAN F.; ALAVIAN S.M.; RAHIMI FARZANEH; HEDAYATI MAHDI; EYNI E.; ZALI MOHAMMAD REZA; AZIZI FEREYDOUN

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Journal: Research in Medicine Year:2007 | Volume:31 | Issue:2 Page(s): 141-145

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Title

SERUM IRON, HEPATIC IRON DEPOSITION, AND INFLAMMATORY HEPATIC NECROSIS/FIBROSIS IN CHRONIC HEPATITIS C

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Keywords

HEPATITIS CQ3

SERUM IRON INDEXQ3

HEPATIC IRON DEPOSITIONQ3

HEPATIC NECROSIS/FIBROSISQ3

Abstract

Background: We studied the effects of serum iron level, HEPATIC IRON DEPOSITION and other metabolic disorders i.e., insulin resistance in hepatic fibrosis development.Materials and methods: Among 60 patients with chronic HEPATITIS C, we measured serum iron, ferritin and transferring level. Meanwhile, hepatic biopsies were obtained from 43 patients for whom iron deposition, inflammatory necrosis/fibrosis score and steatosis were determined.Results: HEPATIC IRON DEPOSITION was significantly associated with waist circumference, ferritin level >200ng/ml, fasting C-peptide >1.9ng/ml, AST/ALT ratio >1, and fasting triglyceride >200mg/dl. On the other hand, it was not correlated with the following: grading, preportal-precital hepatitis (A), necrosis (b), focal lytic necrosis (C), focal apoptosis (C), and portal inflammation (D).Conclusion: Our findings suggested an interaction between HEPATIC IRON DEPOSITION and waist circumference, ferritin, fasting C-peptide, AST/ALT, and fasting triglyceride.

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APA: Copy

MOHAMMADALIZADEH, A.H., FALAHIAN, F., ALAVIAN, S.M., RAHIMI, FARZANEH, HEDAYATI, MAHDI, EYNI, E., ZALI, MOHAMMAD REZA, & AZIZI, FEREYDOUN. (2007). SERUM IRON, HEPATIC IRON DEPOSITION, AND INFLAMMATORY HEPATIC NECROSIS/FIBROSIS IN CHRONIC HEPATITIS C. PAJOUHESH DAR PEZESHKI, 31(2), 141-145. SID. https://sid.ir/paper/41848/en

Vancouver: Copy

MOHAMMADALIZADEH A.H., FALAHIAN F., ALAVIAN S.M., RAHIMI FARZANEH, HEDAYATI MAHDI, EYNI E., ZALI MOHAMMAD REZA, AZIZI FEREYDOUN. SERUM IRON, HEPATIC IRON DEPOSITION, AND INFLAMMATORY HEPATIC NECROSIS/FIBROSIS IN CHRONIC HEPATITIS C. PAJOUHESH DAR PEZESHKI[Internet]. 2007;31(2):141-145. Available from: https://sid.ir/paper/41848/en

IEEE: Copy

A.H. MOHAMMADALIZADEH, F. FALAHIAN, S.M. ALAVIAN, FARZANEH RAHIMI, MAHDI HEDAYATI, E. EYNI, MOHAMMAD REZA ZALI, and FEREYDOUN AZIZI, “SERUM IRON, HEPATIC IRON DEPOSITION, AND INFLAMMATORY HEPATIC NECROSIS/FIBROSIS IN CHRONIC HEPATITIS C,” PAJOUHESH DAR PEZESHKI, vol. 31, no. 2, pp. 141–145, 2007, [Online]. Available: https://sid.ir/paper/41848/en

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