THE EFFECT OF INTRAHIPPOCAMPUS FLUTAMIDE ADMINISTRATION ON SPATIAL LEARNING OF MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAGHDI N.; MAJLESI N.; NAFISI N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Research in Medicine Year:2001 | Volume:24 | Issue:4 Page(s): 327-338

Download Full-Text

Persian Verion

View:

734

Download:

Cites:

Information Journal Paper

Title

THE EFFECT OF INTRAHIPPOCAMPUS FLUTAMIDE ADMINISTRATION ON SPATIAL LEARNING OF MALE RATS

Author(s)

NAGHDI N. | MAJLESI N. | NAFISI N. | Issue Writer Certificate

Keywords

FLUTAMIDEQ2

TESTOSTERONEQ3

HIPPOCAMPUSQ4

MORRIS WATER MAZEQ2

SPATIAL DISCRIMINATIONQ4

Abstract

In most mammals the HIPPOCAMPUS has a well documented role in spatial memory acquisition. The presence of high of AR (Androgenic Receptor) and AR mRNA in the HIPPOCAMPUS suggests that this area is a major neural target for androgens. In addition, androgens have been shown to play a role in learning and memory processes. Therefore, in order to determine the role of androgenic receptors in CAI region, this experiment was conducted to assess the effect of FLUTAMIDE (A non steroidal antiandrogen) administration into the CAI region on spatial memory. Spatial learning was assessed in MORRIS WATER MAZE. For this purpose, male Wistar rats were connulated bilaterally in to the CAI region. The animals divided into 5 groups, were given different doses of FLUTAMIDE (2,5,10, 20 µg/ 0.5 µl)or its vehicle (DMSO) 30 minutes before training each day. The results showed dose dependent increases in latencies and traveled distances to find the invisible platform in FLUTAMIDE received groups compared to the control group with peck effect at doses of 5 µl. Therefore, it appears that spatial localization in the MORRIS WATER MAZE may be impaired by TESTOSTERONE antagonists.

Cites

No record.

References

No record.

Cite

APA: Copy

NAGHDI, N., MAJLESI, N., & NAFISI, N.. (2001). THE EFFECT OF INTRAHIPPOCAMPUS FLUTAMIDE ADMINISTRATION ON SPATIAL LEARNING OF MALE RATS. PAJOUHESH DAR PEZESHKI, 24(4), 327-338. SID. https://sid.ir/paper/41865/en

Vancouver: Copy

NAGHDI N., MAJLESI N., NAFISI N.. THE EFFECT OF INTRAHIPPOCAMPUS FLUTAMIDE ADMINISTRATION ON SPATIAL LEARNING OF MALE RATS. PAJOUHESH DAR PEZESHKI[Internet]. 2001;24(4):327-338. Available from: https://sid.ir/paper/41865/en

IEEE: Copy

N. NAGHDI, N. MAJLESI, and N. NAFISI, “THE EFFECT OF INTRAHIPPOCAMPUS FLUTAMIDE ADMINISTRATION ON SPATIAL LEARNING OF MALE RATS,” PAJOUHESH DAR PEZESHKI, vol. 24, no. 4, pp. 327–338, 2001, [Online]. Available: https://sid.ir/paper/41865/en

Related Journal Papers