INVESTIGATION OF GELATINASE- B ENZYME ROLE IN INVASION AND METASTASIS OF BREAST CANCER

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MOTEVALIBASHI MAJID; HOJATI ZOHREH; SADEGHI MORTEZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Research in Medicine Year:2008 | Volume:32 | Issue:2 Page(s): 89-93

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Title

INVESTIGATION OF GELATINASE- B ENZYME ROLE IN INVASION AND METASTASIS OF BREAST CANCER

Author(s)

MOTEVALIBASHI MAJID | HOJATI ZOHREH | SADEGHI MORTEZA | Issue Writer Certificate

Keywords

BREAST CANCERQ3

GELATINASE BQ1

METASTASISQ3

RFLPQ2

Abstract

Background: GELATINASE B or collagenase type IV is a 92 kDa protein. In case of over-expression of the gene, because of its collagenase activity, it can be involved in METASTASIS activity of few cancers e.g. bladder, colorectal and gastric carcinoma. Single nucleotide substitution base polymorphism of C to T at -1562 of promoter region can increase gene expression by decreasing transcription inhibitor proteins binding at T alleles. The aim of this case-control study is to investigate the role of this polymorphism in development and invasion of BREAST CANCER in Isfahan women population.Materials and methods: At this study 90 BREAST CANCER patients with METASTASIS and 100 healthy controls were analyzed using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). The mean of follow up period was 2 years. Patients were checked every 3-5 months.Results: Data analysis showed a close association between the presence of T allele and invasion of BREAST CANCER (OR=5.85, 95% CI: 2.64-12.93, P<0.0001).Conclusion: According to our findings, the major role of this polymorphism is in cancer cell METASTASIS and invasion of these cells to adjacent tissues.

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APA: Copy

MOTEVALIBASHI, MAJID, HOJATI, ZOHREH, & SADEGHI, MORTEZA. (2008). INVESTIGATION OF GELATINASE- B ENZYME ROLE IN INVASION AND METASTASIS OF BREAST CANCER. PAJOUHESH DAR PEZESHKI, 32(2), 89-93. SID. https://sid.ir/paper/42171/en

Vancouver: Copy

MOTEVALIBASHI MAJID, HOJATI ZOHREH, SADEGHI MORTEZA. INVESTIGATION OF GELATINASE- B ENZYME ROLE IN INVASION AND METASTASIS OF BREAST CANCER. PAJOUHESH DAR PEZESHKI[Internet]. 2008;32(2):89-93. Available from: https://sid.ir/paper/42171/en

IEEE: Copy

MAJID MOTEVALIBASHI, ZOHREH HOJATI, and MORTEZA SADEGHI, “INVESTIGATION OF GELATINASE- B ENZYME ROLE IN INVASION AND METASTASIS OF BREAST CANCER,” PAJOUHESH DAR PEZESHKI, vol. 32, no. 2, pp. 89–93, 2008, [Online]. Available: https://sid.ir/paper/42171/en

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