C29T (PRO10LEU) POLYMORPHISM OF TRANSFORMING GROWTH FACTOR⓵ (TGF-⓵) GENE AND UNEXPLAINED INFERTILITY IN IRAN

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MARHEMATI FARNAZ; MOHSENI MEYBODI ANAHITA; TAHERIPANAH ROBABEH; AMANI DAVAR

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Journal: Research in Medicine Year:2015 | Volume:39 | Issue:1 Page(s): 20-25

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Title

C29T (PRO10LEU) POLYMORPHISM OF TRANSFORMING GROWTH FACTOR⓵ (TGF-⓵) GENE AND UNEXPLAINED INFERTILITY IN IRAN

Author(s)

MARHEMATI FARNAZ | MOHSENI MEYBODI ANAHITA | TAHERIPANAH ROBABEH | AMANI DAVAR | Issue Writer Certificate

Keywords

INFERTILITYQ2

POLYMORPHISMQ2

CYTOKINEQ2

TGF-⓵ GENEQ2

UNEXPLAINED INFERTILITYQ3

Abstract

Background: The increasing incidence of INFERTILITY is alarming. About %30-10 of infertilities are classified as unexplained INFERTILITY (UI), which is not an absolute clinical condition. TGF-b1 is multifunctional CYTOKINE and produced mainly by T regulatory (Treg) lymphocytes. This CYTOKINE plays an important role in physiology of normal pregnancy. The association of single nucleotide POLYMORPHISMs (SNPs) of TGF-b1 gene with many immunologic diseases has been reported. In this study, the association of TGF-b1 C29T (Pro10Leu) gene POLYMORPHISM with unexplained INFERTILITY was investigated in Iranian UI patients.Materials and Methods: In this case-control study blood samples were collected from 177 UI patients (142 male and 35 female) and 336 controls (232 male and 104 female) with no history of INFERTILITY. DNA was extracted by salting out method. Analysis of the TGF-b1 gene POLYMORPHISM C29T (Pro10Leu) was performed by PCR and automated sequencing method.Results: The genotype distributions and allele frequencies of TGF-b1 gene C29T (Pro10Leu) POLYMORPHISM were not statistically significant between different categories of UI patients and control group (p>0.05).Conclusion: The results of this study showed, C29T (Pro10Leu) POLYMORPHISM of TGF-b1 gene may not be associated with unexplained INFERTILITY and further studies are necessary to clarify the association of TGF-b1 POLYMORPHISMs and susceptibility to unexplained INFERTILITY.

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APA: Copy

MARHEMATI, FARNAZ, MOHSENI MEYBODI, ANAHITA, TAHERIPANAH, ROBABEH, & AMANI, DAVAR. (2015). C29T (PRO10LEU) POLYMORPHISM OF TRANSFORMING GROWTH FACTOR⓵ (TGF-⓵) GENE AND UNEXPLAINED INFERTILITY IN IRAN. PAJOUHESH DAR PEZESHKI, 39(1), 20-25. SID. https://sid.ir/paper/42186/en

Vancouver: Copy

MARHEMATI FARNAZ, MOHSENI MEYBODI ANAHITA, TAHERIPANAH ROBABEH, AMANI DAVAR. C29T (PRO10LEU) POLYMORPHISM OF TRANSFORMING GROWTH FACTOR⓵ (TGF-⓵) GENE AND UNEXPLAINED INFERTILITY IN IRAN. PAJOUHESH DAR PEZESHKI[Internet]. 2015;39(1):20-25. Available from: https://sid.ir/paper/42186/en

IEEE: Copy

FARNAZ MARHEMATI, ANAHITA MOHSENI MEYBODI, ROBABEH TAHERIPANAH, and DAVAR AMANI, “C29T (PRO10LEU) POLYMORPHISM OF TRANSFORMING GROWTH FACTOR⓵ (TGF-⓵) GENE AND UNEXPLAINED INFERTILITY IN IRAN,” PAJOUHESH DAR PEZESHKI, vol. 39, no. 1, pp. 20–25, 2015, [Online]. Available: https://sid.ir/paper/42186/en

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