COMPARATIVE EFFICACY OF NEW ANTIBACTERIAL COMPOUNDS AGAINST YERSINIA ENTROLITICA

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Beyzaei Hamid; GHASEMI BEHZAD; Mirzaie Mojtaba; Sanjarani Ghasem

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Journal: Research in Medicine Year:2018 | Volume:42 | Issue:1 Page(s): 15-20

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Title

COMPARATIVE EFFICACY OF NEW ANTIBACTERIAL COMPOUNDS AGAINST YERSINIA ENTROLITICA

Author(s)

Beyzaei Hamid | GHASEMI BEHZAD | Mirzaie Mojtaba | Sanjarani Ghasem | Issue Writer Certificate

Keywords

ANTIBACTERIAL EFFECTQ2

Y. ENTEROCOLITICAQ1

MAGNESIUM OXIDE NANOPARTICLEQ1

THIAZOLEQ1

IMIDAZOLIDINEQ1

TETRAHYDROPYRIMIDINEQ1

POLY-L-LYSINEQ1

GLYCINEQ1

Abstract

Background: Yersinia enterocolitica is a zoonotic pathogen and one of important gastroenteritis agents. Some drug-resistant strains of this bacterium were previously discovered in the world and using new antibacterial compounds is one of the best ways to deal with it. In the present study, inhibitory effects of MAGNESIUM OXIDE NANOPARTICLEs, some heterocycles including THIAZOLE, IMIDAZOLIDINE and TETRAHYDROPYRIMIDINE derivatives, POLY-L-LYSINE, and GLYCINE were assessed against standard strains of Y. ENTEROCOLITICA. Materials and Methods: In the current experiential laboratory study, ANTIBACTERIAL EFFECTs of all compounds were evaluated using the disk diffusion and broth microdilution methods. The results were reported as inhibition zone diameter (IZD), the minimum inhibitory concentration (MIC), and the minimum bactericidal concentration (MBC) values. Data were analyzed using SPSS, version 19.0 (SPSS Inc., Chicago, USA) running t-test and ANOVA.Results: No inhibitory activity against Y. ENTEROCOLITICA was observed by MgO nanoparticles, POLY-L-LYSINE and GLYCINE. THIAZOLE derivative 7c was the only effective antibacterial agent on this bacteria with inhibition zone diameter 6.3±0.1, MIC 512, and MBC 1024 mg/ml with P-value<0.05.conclusion: Considering the ANTIBACTERIAL EFFECTs of compound 7c against standard strains of Y. ENTEROCOLITICA, inhibitory activities of this compound against antibiotic-resistant strains of Y. ENTEROCOLITICA as well as its toxic and therapeutic effects on laboratory animals should be investigated in further studies. Also, THIAZOLE 7c can be introduced as a new antibacterial agent.

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APA: Copy

Beyzaei, Hamid, GHASEMI, BEHZAD, Mirzaie, Mojtaba, & Sanjarani, Ghasem. (2018). COMPARATIVE EFFICACY OF NEW ANTIBACTERIAL COMPOUNDS AGAINST YERSINIA ENTROLITICA. PAJOUHESH DAR PEZESHKI, 42(1 ), 15-20. SID. https://sid.ir/paper/42217/en

Vancouver: Copy

Beyzaei Hamid, GHASEMI BEHZAD, Mirzaie Mojtaba, Sanjarani Ghasem. COMPARATIVE EFFICACY OF NEW ANTIBACTERIAL COMPOUNDS AGAINST YERSINIA ENTROLITICA. PAJOUHESH DAR PEZESHKI[Internet]. 2018;42(1 ):15-20. Available from: https://sid.ir/paper/42217/en

IEEE: Copy

Hamid Beyzaei, BEHZAD GHASEMI, Mojtaba Mirzaie, and Ghasem Sanjarani, “COMPARATIVE EFFICACY OF NEW ANTIBACTERIAL COMPOUNDS AGAINST YERSINIA ENTROLITICA,” PAJOUHESH DAR PEZESHKI, vol. 42, no. 1 , pp. 15–20, 2018, [Online]. Available: https://sid.ir/paper/42217/en

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