COMPARISON OF 2 TECHNIQUE ADJUNCTIVE ANTIMETABOLITE TRABECULECTOMY IN CASES WITH HIGH RISK FOR FAILURE: 0.01% MITOMYCIN (MMC) WITH POSTOP 5-FLUOROURACIL INJECTIONS VS. INTRAOPERATIVE 0.027% MITOMYCIN APPLICATION

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KARIMIAN F.; NASIRI N.; JAVADI M.A.; VELAEI N.; ESLAMI E.; FALAHI MOTLAGH B.

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Journal: BINA Year:2000 | Volume:5 | Issue:3 Page(s): 245-251

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Title

COMPARISON OF 2 TECHNIQUE ADJUNCTIVE ANTIMETABOLITE TRABECULECTOMY IN CASES WITH HIGH RISK FOR FAILURE: 0.01% MITOMYCIN (MMC) WITH POSTOP 5-FLUOROURACIL INJECTIONS VS. INTRAOPERATIVE 0.027% MITOMYCIN APPLICATION

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Abstract

Background: Dosage of adjunctive antimetabolites applied in trabeculectomies with high risk for failure remains controversial.Purpose: To compare two techniques of adjunctive antimetabolit application in cases of trabeculectomy with high risk for failure.Material and Methods: In a clinical trial, adjunctive antimetabolite trabeculectomies were performed for 24 eyes of 29 patients in which glaucomas were poor controlled with tolerable medications. This cases had one of the risk factors for failure: aphakia or pseudophakia, failed previous trabeculectomy (ies), neovascular glaucoma, uveitic glaucoma, age of less than 40 years. Trabeculectomies were randomized in two groups. In control group, intraoperative 0.027% MMC for 3 minutes and in experimental group intraoperative 0.01% MMC for 3 minutes plus 5 daily postop subconjuctival injections of 5-flurouracil were used.Results: Fifteen eyes in control group were compared with 14 eyes in experimental group. Age, sex, type of glaucoma, intraocular pressure, preop number of used medications in both group were comparable. Patients had at least 6 months of follow up. Mean intraocular pressures of 2 groups in all follow up intervals had no statistically difference. There was no case of bleb or wound leakage, suprachoroidal hemorrhage, scleritis or hypotonia maculopathy in both groups. Shallowing of anterior chamber occurred in 33 percent of control group but none in experimental group (P<0.02). Serous choroidal detachment and hypotonia were not statistically different in two groups.Conclusion: Both techniques of adjunctive antimetabolite trabeculectomies had equal effect with comparable side effects. Other studies with more cases and longer follow up time is recommended.

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APA: Copy

KARIMIAN, F., NASIRI, N., JAVADI, M.A., VELAEI, N., ESLAMI, E., & FALAHI MOTLAGH, B.. (2000). COMPARISON OF 2 TECHNIQUE ADJUNCTIVE ANTIMETABOLITE TRABECULECTOMY IN CASES WITH HIGH RISK FOR FAILURE: 0.01% MITOMYCIN (MMC) WITH POSTOP 5-FLUOROURACIL INJECTIONS VS. INTRAOPERATIVE 0.027% MITOMYCIN APPLICATION. BINA, 5(3), 245-251. SID. https://sid.ir/paper/43006/en

Vancouver: Copy

KARIMIAN F., NASIRI N., JAVADI M.A., VELAEI N., ESLAMI E., FALAHI MOTLAGH B.. COMPARISON OF 2 TECHNIQUE ADJUNCTIVE ANTIMETABOLITE TRABECULECTOMY IN CASES WITH HIGH RISK FOR FAILURE: 0.01% MITOMYCIN (MMC) WITH POSTOP 5-FLUOROURACIL INJECTIONS VS. INTRAOPERATIVE 0.027% MITOMYCIN APPLICATION. BINA[Internet]. 2000;5(3):245-251. Available from: https://sid.ir/paper/43006/en

IEEE: Copy

F. KARIMIAN, N. NASIRI, M.A. JAVADI, N. VELAEI, E. ESLAMI, and B. FALAHI MOTLAGH, “COMPARISON OF 2 TECHNIQUE ADJUNCTIVE ANTIMETABOLITE TRABECULECTOMY IN CASES WITH HIGH RISK FOR FAILURE: 0.01% MITOMYCIN (MMC) WITH POSTOP 5-FLUOROURACIL INJECTIONS VS. INTRAOPERATIVE 0.027% MITOMYCIN APPLICATION,” BINA, vol. 5, no. 3, pp. 245–251, 2000, [Online]. Available: https://sid.ir/paper/43006/en

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