THE EFFECT OF MULTIPLE SCLEROSIS ON SPERMATOGENSIS AND SEX HOROMONE OF WISTAR RATS

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AZARNIA MAHNAZ; KHALILI MOHAMMAD ALI; ROSTAMI P.; KHADEM ALHOSSEINI M.R.

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Journal: JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY) Year:2005 | Volume:5 | Issue:1-2 Page(s): 487-496

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Title

THE EFFECT OF MULTIPLE SCLEROSIS ON SPERMATOGENSIS AND SEX HOROMONE OF WISTAR RATS

Author(s)

AZARNIA MAHNAZ | KHALILI MOHAMMAD ALI | ROSTAMI P. | KHADEM ALHOSSEINI M.R. | Issue Writer Certificate

Keywords

ETHIDIUM BROMIDEQ4

MSQ4

SPERMQ4

DEMYELINATIONQ3

EAEQ4

Abstract

Multiple sclerosis (MS) is one of the degenerative diseases of the central nervous system (CNS), which results in the destruction of myelin sheath. MS could be induced in laboratory animals, by injection of ETHIDIUM BROMIDE (EB) into Cerebrospinal Fluid (CSF). This disease may cause impotence or subfertility in men. The objective of this study was to evaluate the role of MS on SPERMatogenesis, SPERM parameters such as... and sex hormones of wistar rats. A total of 36 rats (5 weeks old) were divided into 3 groups of control, sham and experimental. 20ul of physiological saline was injected into cerebellomedullary cistern (CC) of rats in sham group, and, 20ul of EB was injected into CC of experimental group. One week after EB injection, two rats from each group were killed randomly to investigate the morphology of pons. The rest were killed 5 weeks after injections to study the SPERMatogenic cells, SPERM parameters and sex hormones. The results showed that SPERM progressive motility was significantly reduced from 74.4±2.2 in control group to 60.6±1.4 in experimental group (p<0/001). Also, the number of round cells was increased from /73±0/1 in control group to 2.16±/25 in experimental group (p</001). However, the number of SPERMatogonial cells, primary SPERMatocytes, and SPERMatids were insignificantly reduced in experimental group. The number of SPERMatozoa as well as leydig cells was reduced in experimental group comparing with other groups (p<0/05).Concentrations of FSH, LH and testosterone in experimental group have also reduced. In conclusion, experimental MS. can alter the SPERMatogenic cells, SPERM motility, as well as FSH, LH and testosterone hormones concentrations, which may influence the fertility potentials of rats.

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APA: Copy

AZARNIA, MAHNAZ, KHALILI, MOHAMMAD ALI, ROSTAMI, P., & KHADEM ALHOSSEINI, M.R.. (2005). THE EFFECT OF MULTIPLE SCLEROSIS ON SPERMATOGENSIS AND SEX HOROMONE OF WISTAR RATS. JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY), 5(1-2), 487-496. SID. https://sid.ir/paper/43903/en

Vancouver: Copy

AZARNIA MAHNAZ, KHALILI MOHAMMAD ALI, ROSTAMI P., KHADEM ALHOSSEINI M.R.. THE EFFECT OF MULTIPLE SCLEROSIS ON SPERMATOGENSIS AND SEX HOROMONE OF WISTAR RATS. JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY)[Internet]. 2005;5(1-2):487-496. Available from: https://sid.ir/paper/43903/en

IEEE: Copy

MAHNAZ AZARNIA, MOHAMMAD ALI KHALILI, P. ROSTAMI, and M.R. KHADEM ALHOSSEINI, “THE EFFECT OF MULTIPLE SCLEROSIS ON SPERMATOGENSIS AND SEX HOROMONE OF WISTAR RATS,” JOURNAL OF SCIENCE (KHARAZMI UNIVERSITY), vol. 5, no. 1-2, pp. 487–496, 2005, [Online]. Available: https://sid.ir/paper/43903/en

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