COMPARISON OF SODIUM DICLOFENAC AND BETAMETHASONE EYE DROP IN PREVENTING CYSTOID MACULAR EDEMA AFTER EXTRA CAPSULAR CATARACT SURGERY

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AHMAD ZADEH AMIRI A.; SHEIKH REZAEI M.R.; ESHAGHI M.; FAROKHFAR A.; NOROOZPOOR DAILAMI Q.

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2003 | Volume:13 | Issue:39 Page(s): 48-54

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Title

COMPARISON OF SODIUM DICLOFENAC AND BETAMETHASONE EYE DROP IN PREVENTING CYSTOID MACULAR EDEMA AFTER EXTRA CAPSULAR CATARACT SURGERY

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Keywords

MACULAR EDEMA-CYSTOIDQ4

DICELOFENAC SODIUMQ3

BETAMETHASONEQ3

OPHTHALMIC SOLUTIONSQ4

CATARACT-SURGERYQ4

Abstract

Background and purpose: Since Cystoid Macular Edema (CME) is caused by ocular inflammation after cataract surgery. Its control with suitable medication is reasonable. Aim of this study was to compare a nonsteroidal topical solution (0.1% diclofenac) to a steroidal topical solution (0.1% BETAMETHASONE) in preventing CME after extra capsular cataract surgery.Materials and methods: A prospective randomized double blind clinical trial was performed on patients undergoing extra capsular cataract surgery with posterior chamber lens implantation. By simple randomizing method, patients were divided in two groups on the basis of diclofenac 0.1% and BETAMETHASONE 0.1%. All patients had similar condition of ocular background (cataract) surgical procedures and inter ocular implantation in two groups. The presence and degree of CME were determined by fluorescin angiography. A breakdown of the blood-aqueous barrier was determined by anterior chamber cells and flare biomicroscopy.Results: Six weeks after surgery, CME was present in 2 of 47 eyes (4.25%) receiving diclofenac and in 12 of 50 eyes (24%) receiving BETAMETHASONE. There was no significant difference in cellular reaction in the anterior chamber at 3 days, 1 and 6 weeks after surgery between two groups (P<0.01). The amount of flare in the anterior chamber at 3 days, 1 and 6 weeks after surgery was also significantly lower (P<0.001) in diclofenac group. Also extra ocular inflammation declined in diclofenac group (P<0.001).Conclusion: These finding shows that diclofenac effectively prevents CME following cataract surgery and indicating that, CME is closely related to the post surgical intra ocular inflammation, also diclofenac can effectively reduce ocular inflammation and the occurrence of CME.

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APA: Copy

AHMAD ZADEH AMIRI, A., SHEIKH REZAEI, M.R., ESHAGHI, M., FAROKHFAR, A., & NOROOZPOOR DAILAMI, Q.. (2003). COMPARISON OF SODIUM DICLOFENAC AND BETAMETHASONE EYE DROP IN PREVENTING CYSTOID MACULAR EDEMA AFTER EXTRA CAPSULAR CATARACT SURGERY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 13(39), 48-54. SID. https://sid.ir/paper/44166/en

Vancouver: Copy

AHMAD ZADEH AMIRI A., SHEIKH REZAEI M.R., ESHAGHI M., FAROKHFAR A., NOROOZPOOR DAILAMI Q.. COMPARISON OF SODIUM DICLOFENAC AND BETAMETHASONE EYE DROP IN PREVENTING CYSTOID MACULAR EDEMA AFTER EXTRA CAPSULAR CATARACT SURGERY. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2003;13(39):48-54. Available from: https://sid.ir/paper/44166/en

IEEE: Copy

A. AHMAD ZADEH AMIRI, M.R. SHEIKH REZAEI, M. ESHAGHI, A. FAROKHFAR, and Q. NOROOZPOOR DAILAMI, “COMPARISON OF SODIUM DICLOFENAC AND BETAMETHASONE EYE DROP IN PREVENTING CYSTOID MACULAR EDEMA AFTER EXTRA CAPSULAR CATARACT SURGERY,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 13, no. 39, pp. 48–54, 2003, [Online]. Available: https://sid.ir/paper/44166/en

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