THE SERUM LEVELS OF TH1 AND TH2 CYTOKINE PROFILES IN PATIENTS WITH DIFFERENT STAGES OF CHRONIC KIDNEY DISEASE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RAFIEI ALI REZA; MAKHLOUGH A.; HASHEMINASAB SADEGH; HOSSEINIAN AMIRI A.; ABEDIAN F.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:18 | Issue:63 Page(s): 37-45

Download Full-Text

Persian Verion

View:

674

Download:

Cites:

Information Journal Paper

Title

THE SERUM LEVELS OF TH1 AND TH2 CYTOKINE PROFILES IN PATIENTS WITH DIFFERENT STAGES OF CHRONIC KIDNEY DISEASE

Author(s)

Keywords

CHRONIC RENAL FAILUREQ2

IL-13 AND IFN-γQ3

HEAMODIALYSISQ3

Abstract

Background and Purpose: Various abnormalities of the immune system have been demonstrated in patients with chronic kidney disease (CKD). Patients with CKD commonly present with abnormalities of immune function related with impaired kidney function and the accumulation of uremic toxins. Th1 and Th2 cells produce predominantly some cytokine profiles. The aim of the present study was the determination of the levels of IL-13 and IFN-g in sera of end-stage renal disease. The correlations of IL-13 and IFN-g levels with clinical presentation of the disease were assessed.Materials and Methods: In this case-control study the serum levels of IL-13 and IFN-g were determined by a sandwich enzyme-linked immunosorbent assay in 30 patients on hemodialysis (HD), 30 patients with CHRONIC RENAL FAILURE (CRF), and 60 healthy individuals. Renal function was evaluated by measuring serum levels of creatinin, albumin and urea.Results: The serum levels of IL-13 and IFN-g were differed significantly between patients and healthy controls. The serum levels of IL-13 was significantly increased in the HD group than in the CRF and control groups (13.7±3.9, 6.7±3.4, 4.5±3.3 pg/ml, respectively) (P=0.001). On the other hand, the IFN-g plasma levels were significantly higher in CRF patients than HD patients and controls (38.8±18.8, 17.4±8.78, 12.5±8.9 pg/ml, respectively).Conclusion: In the HD patients, low production of IFN-g in line with upregulation of IL-13 indicates that Th1/Th2 balance may shift towards Th2 dominance. It is possible that this imbalance contributes to the abnormality of the immune system in HD patients.

Cites

No record.

References

No record.

Cite

APA: Copy

RAFIEI, ALI REZA, MAKHLOUGH, A., HASHEMINASAB, SADEGH, HOSSEINIAN AMIRI, A., & ABEDIAN, F.. (2008). THE SERUM LEVELS OF TH1 AND TH2 CYTOKINE PROFILES IN PATIENTS WITH DIFFERENT STAGES OF CHRONIC KIDNEY DISEASE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 18(63), 37-45. SID. https://sid.ir/paper/44305/en

Vancouver: Copy

RAFIEI ALI REZA, MAKHLOUGH A., HASHEMINASAB SADEGH, HOSSEINIAN AMIRI A., ABEDIAN F.. THE SERUM LEVELS OF TH1 AND TH2 CYTOKINE PROFILES IN PATIENTS WITH DIFFERENT STAGES OF CHRONIC KIDNEY DISEASE. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;18(63):37-45. Available from: https://sid.ir/paper/44305/en

IEEE: Copy

ALI REZA RAFIEI, A. MAKHLOUGH, SADEGH HASHEMINASAB, A. HOSSEINIAN AMIRI, and F. ABEDIAN, “THE SERUM LEVELS OF TH1 AND TH2 CYTOKINE PROFILES IN PATIENTS WITH DIFFERENT STAGES OF CHRONIC KIDNEY DISEASE,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 63, pp. 37–45, 2008, [Online]. Available: https://sid.ir/paper/44305/en

Related Journal Papers