INFLUENCE OF DIFFERENT HISTAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON APOMORPHINE-INDUCED LICKING BEHAVIOUR IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FARZIN D.; ATTARZADEH M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2002 | Volume:12 | Issue:34 Page(s): 9-17

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,579

Download:

Cites:

Information Journal Paper

Title

INFLUENCE OF DIFFERENT HISTAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON APOMORPHINE-INDUCED LICKING BEHAVIOUR IN RAT

Author(s)

FARZIN D. | ATTARZADEH M. | Issue Writer Certificate

Keywords

HISTAMINE AGONISTSQ4

DOPAMINE ANTAGONISTSQ3

APOMORPHINEQ4

RATSQ2

BEHAVIOURQ3

Abstract

Background and purpose: Repetitive licking BEHAVIOUR is a stereotyped phenomenon that is correlated with activation of the nigrostriatal system, and is thought to be produced by activation of both postsynaptic dopamine D1 and D2 receptors. There are good evidences showing that the histaminergic mechanisms may be closely related to dopaminergic systems, and play an important modulatory role in various BEHAVIOURs induced by dopaminergic agents. In order to clarify the possible role of the histaminergic mechanism(s) in the modulation of licking BEHAVIOUR, the effects of several histamine receptor agonists and antagonists were studied on the licking BEHAVIOUR induced by APOMORPHINE in the rat.Materials and methods: Subcutaneous (s.c.) injection of various doses of APOMORPHINE (0.125-1.25 mg/kg) induced licking. The licking response was counted by direct observation and recorded for a period of 75 min. Results: Intracerebroventricular (i.c.v.) or intraperitoneal (i.p.) injection of the histamine H1 or H2 receptor agonists, HTMT (50 and 100 µg per rat), or dimaprit (10-15mg/kg, i.p.), respectively, potentiated APOMORPHINE-induced licking, while imetit (5 and 10 mg/kg, i.p.), reduced the licking response. Pretreatment with various histamine receptor antagonists, dexchlorpheniramine, diphenhydramine, famotidine and ranitidine reduced APOMORPHINE-induced licking, while thioperamide potentiated the APOMORPHINE effect. The effects of HTMT and dimaprit were blocked by dexchlorpheniramine and famotidine respectively. The inhibitory effect elicited by imetit was also abolished with thioperamide.Conclusion: The results suggest that histaminergic mechanisms may be involved in the modulation of APOMORPHINE-induced licking BEHAVIOUR.

Cites

No record.

References

No record.

Cite

APA: Copy

FARZIN, D., & ATTARZADEH, M.. (2002). INFLUENCE OF DIFFERENT HISTAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON APOMORPHINE-INDUCED LICKING BEHAVIOUR IN RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 12(34), 9-17. SID. https://sid.ir/paper/44367/en

Vancouver: Copy

FARZIN D., ATTARZADEH M.. INFLUENCE OF DIFFERENT HISTAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON APOMORPHINE-INDUCED LICKING BEHAVIOUR IN RAT. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;12(34):9-17. Available from: https://sid.ir/paper/44367/en

IEEE: Copy

D. FARZIN, and M. ATTARZADEH, “INFLUENCE OF DIFFERENT HISTAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON APOMORPHINE-INDUCED LICKING BEHAVIOUR IN RAT,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 12, no. 34, pp. 9–17, 2002, [Online]. Available: https://sid.ir/paper/44367/en

Related Journal Papers